TY - JOUR
T1 - Bone mineral density among systemic lupus erythematosus patient age 5-18 years with glucocorticoid treatment in child and adolescent outpatient clinic, Cipto Mangunkusumo Hospital, Jakarta
AU - Indriyani, N.
AU - Tridjaja, B.
AU - Medise, B. E.
AU - Kurniati, N.
N1 - Funding Information:
All data were numbered in research report forms, which were prepared and entered into the computer database using the SPSS program version 22 for Windows; this software was employed for data analysis. The statistical analyses involved the Shapiro-Wilk test, Z scores for different characteristics and laboratory parameters related to bone mineral density, and scatterplots of the bone mineral density Z scores according to the cumulative dose of corticosteroids. This study was approved by the Commission of Ethics Research, Medical Faculty Universitas Indonesia.
Publisher Copyright:
© Published under licence by IOP Publishing Ltd.
PY - 2017/8/30
Y1 - 2017/8/30
N2 - Systemic lupus erythematosus (SLE) is an autoimmune disease affecting children; its morbidity and mortality rates are significant. One risk factor for morbidity is chronic corticosteroid use. The aim of this study is to determine the occurrence rate of low bone mineral density; discuss the characteristics, including cumulative and daily doses of corticosteroid, body mass index, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), calcium, and Vitamin D intake; and assess bone metabolism laboratory parameters, including serum calcium, Vitamin D, alkaline phosphatase (ALP), phosphorus, and cortisol among children with SLE receiving corticosteroids. This was a descriptive, cross-sectional study involving 16 children with SLE attending the child and adolescent outpatient clinic at Cipto Mangunkusumo Hospital in November-December 2016. Low bone mineral density occurred among 7/16 patients. The mean total bone mineral density was 0.885 ±0.09 g/cm2. Children with SLE receiving corticosteroid had low calcium (8.69 ±0.50 mg/dl), Vitamin D (19.3 ±5.4 mg/dl), ALP (79.50 [43.00-164.00] U/l), and morning cortisol level (1.20 [0.0-10.21] ug/dl), as well as calcium (587.58 ±213.29 mg/d) and Vitamin D (2.9 [0-31.8] mcg/d) intake. The occurrence of low bone mineral density was observed among children with SLE receiving corticosteroid treatment. Low bone mineral density tends to occur among patients with higher cumulative doses and longer duration of corticosteroid treatments.
AB - Systemic lupus erythematosus (SLE) is an autoimmune disease affecting children; its morbidity and mortality rates are significant. One risk factor for morbidity is chronic corticosteroid use. The aim of this study is to determine the occurrence rate of low bone mineral density; discuss the characteristics, including cumulative and daily doses of corticosteroid, body mass index, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), calcium, and Vitamin D intake; and assess bone metabolism laboratory parameters, including serum calcium, Vitamin D, alkaline phosphatase (ALP), phosphorus, and cortisol among children with SLE receiving corticosteroids. This was a descriptive, cross-sectional study involving 16 children with SLE attending the child and adolescent outpatient clinic at Cipto Mangunkusumo Hospital in November-December 2016. Low bone mineral density occurred among 7/16 patients. The mean total bone mineral density was 0.885 ±0.09 g/cm2. Children with SLE receiving corticosteroid had low calcium (8.69 ±0.50 mg/dl), Vitamin D (19.3 ±5.4 mg/dl), ALP (79.50 [43.00-164.00] U/l), and morning cortisol level (1.20 [0.0-10.21] ug/dl), as well as calcium (587.58 ±213.29 mg/d) and Vitamin D (2.9 [0-31.8] mcg/d) intake. The occurrence of low bone mineral density was observed among children with SLE receiving corticosteroid treatment. Low bone mineral density tends to occur among patients with higher cumulative doses and longer duration of corticosteroid treatments.
UR - http://www.scopus.com/inward/record.url?scp=85029573777&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/884/1/012078
DO - 10.1088/1742-6596/884/1/012078
M3 - Conference article
AN - SCOPUS:85029573777
SN - 1742-6588
VL - 884
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
IS - 1
M1 - 012078
T2 - 1st Physics and Technologies in Medicine and Dentistry Symposium, PTMDS 2017
Y2 - 15 July 2017 through 16 July 2017
ER -