Bone metabolism and fracture risk in diabetes mellitus

Melisa Puspitasari, Dyah Purnamasari, Bambang Setyohadi, Harry Isbagio

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Individuals with Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are at increased risk for fragility fractures. Bone mineral density (BMD) is decreased in TLDM but often normal or even elevated in T2DM when compared with age-matched non-DM populations. However, bone turnover is decreased in both T1DM and T2DM. The pathophysiologic mechanisms leading to bone fragility is multifactorial, and potentially leads to reduced bone formation, altered bone microstructure and decreased bone strength. Interestingly, different antidiabetic treatments may influence fracture risk due to effects on glycemic control, triggering of hypoglycemic events or osteoblastogenesis.

Original languageEnglish
Pages (from-to)90-99
Number of pages10
JournalJournal of the ASEAN Federation of Endocrine Societies
Volume32
Issue number2
DOIs
Publication statusPublished - Nov 2017

Keywords

  • Biomarkers
  • Bone metabolism
  • Bone remodeling
  • Diabetes mellitus

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