TY - JOUR
T1 - Body fat percentage is a better marker than body mass index for determining inflammation status in polycystic ovary syndrome
AU - Hestiantoro, Andon
AU - Hasani, Rachmat Dediat Kapnosa
AU - Shadrina, Amalia
AU - Situmorang, Herbert
AU - Ilma, Nurul
AU - Muharam, Raden
AU - Sumapraja, Kanadi
AU - Wiweko, Budi
N1 - Publisher Copyright:
© 2018, Research and Clinical Center for Infertitlity. All rights reserved.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Background: Polycystic ovary syndrome (PCOS) is an endocrinopathic disorder most commonly experienced by women of reproductive age, and it is characterized by a low-grade chronic inflammatory condition. Excessive fat deposit has been long considered as an etiological factor in the pathogenesis of this inflammatory condition. Currently, body mass index (BMI) or percentage of body fat is used as a marker to assess the body fat composition of a person. Objective: To determine whether BMI or body fat percentage (BFP) can be used as a better marker for measuring inflammation related to body fat accumulation in polycystic ovary syndrome patients. Materials and Methods: This study took place at the Center for Reproductive Medicine, Yasmin Clinic, Cipto Mangunkusumo Hospital from January to December 2015. In this cross-sectional study, 32 reproductive age women with PCOS according to the Rotterdam criteria (2003) participated. Women with hyperandrogenism caused by non-classic congenital adrenal hyperplasia, pregnant and lactating women, etc., were excluded. Some variables such as BMI, clinical hyperandrogenism sign, BFP, and inflammatory markers were assessed and statistically analyzed. Results: From a total of 32 subjects of the study, BFP had a significant positive correlation with procalcitonin levels (r=0.35; p=0.048), while BMI did not (r=0.27; p=0.131). Conclusion: BFP can be used as a better marker for measuring inflammation related to body fat accumulation in PCOS subjects.
AB - Background: Polycystic ovary syndrome (PCOS) is an endocrinopathic disorder most commonly experienced by women of reproductive age, and it is characterized by a low-grade chronic inflammatory condition. Excessive fat deposit has been long considered as an etiological factor in the pathogenesis of this inflammatory condition. Currently, body mass index (BMI) or percentage of body fat is used as a marker to assess the body fat composition of a person. Objective: To determine whether BMI or body fat percentage (BFP) can be used as a better marker for measuring inflammation related to body fat accumulation in polycystic ovary syndrome patients. Materials and Methods: This study took place at the Center for Reproductive Medicine, Yasmin Clinic, Cipto Mangunkusumo Hospital from January to December 2015. In this cross-sectional study, 32 reproductive age women with PCOS according to the Rotterdam criteria (2003) participated. Women with hyperandrogenism caused by non-classic congenital adrenal hyperplasia, pregnant and lactating women, etc., were excluded. Some variables such as BMI, clinical hyperandrogenism sign, BFP, and inflammatory markers were assessed and statistically analyzed. Results: From a total of 32 subjects of the study, BFP had a significant positive correlation with procalcitonin levels (r=0.35; p=0.048), while BMI did not (r=0.27; p=0.131). Conclusion: BFP can be used as a better marker for measuring inflammation related to body fat accumulation in PCOS subjects.
KW - Body fat
KW - Body mass index
KW - Inflammation
KW - Polycystic ovary syndrome
KW - Procalcitonin
UR - http://www.scopus.com/inward/record.url?scp=85063670757&partnerID=8YFLogxK
U2 - 10.29252/ijrm.16.10.623
DO - 10.29252/ijrm.16.10.623
M3 - Article
AN - SCOPUS:85063670757
SN - 2476-4108
VL - 16
SP - 623
EP - 628
JO - International Journal of Reproductive BioMedicine
JF - International Journal of Reproductive BioMedicine
IS - 10
ER -