BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia‐Pacific region

Dyna Khuon; Dhanushi Rupasinghe; Vonthanak Saphonn; Tsz‐shan Kwong; Alvina Widhani; Romanee Chaiwarith; Penh Sun Ly; Cuong Duy Do; Anchalee Avihingsanon; Suwimon Khusuwan; Tuti Parwati Merati; Kinh Van Nguyen; Nagalingeswaran Kumarasamy; Yu‐jiun Chan; Iskandar Azwa; Oon Tek Ng; Sasisopin Kiertiburanakul; Junko Tanuma; Sanjay Pujari; Rossana Ditangco; Fujie Zhang; Jun Yong Choi; Yasmin Gani; Shashikala Sangle; Jeremy Ross; Pamina M. Gorbach; Awachana Jiamsakul

doi:10.1111/hiv.13351

BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia‐Pacific region

Dyna Khuon, Dhanushi Rupasinghe, Vonthanak Saphonn, Tsz‐shan Kwong, Alvina Widhani, Romanee Chaiwarith, Penh Sun Ly, Cuong Duy Do, Anchalee Avihingsanon, Suwimon Khusuwan, Tuti Parwati Merati, Kinh Van Nguyen, Nagalingeswaran Kumarasamy, Yu‐jiun Chan, Iskandar Azwa, Oon Tek Ng, Sasisopin Kiertiburanakul, Junko Tanuma, Sanjay Pujari, Rossana DitangcoFujie Zhang, Jun Yong Choi, Yasmin Gani, Shashikala Sangle, Jeremy Ross, Pamina M. Gorbach, Awachana Jiamsakul

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background
Non-Asian body mass index (BMI) classifications are commonly used as a risk factor for high fasting blood glucose (FBG). We investigated the incidence and factors associated with high FBG among people living with HIV in the Asia-Pacific region, using a World Health Organization BMI classification specific to Asian populations.

Methods
This study included people living with HIV enrolled in a longitudinal cohort study from 2003 to 2019, receiving antiretroviral therapy (ART), and without prior tuberculosis. BMI at ART initiation was categorized using Asian BMI classifications: underweight (
Results
A total of 3939 people living with HIV (63% male) were included. In total, 50% had a BMI in the normal weight range, 23% were underweight, 13% were overweight, and 14% were obese. Median age at ART initiation was 34 years (interquartile range 29–41). Overall, 8% had a high FBG, with an incidence rate of 1.14 per 100 person-years. Factors associated with an increased hazard of high FBG included being obese (≥25 kg/m2) compared with normal weight (hazard ratio [HR] = 1.79; 95% confidence interval [CI] 1.31–2.44; p
Conclusion
People living with HIV with BMI >25 kg/m2 were at increased risk of high FBG. This indicates that regular assessments should be performed in those with high BMI, irrespective of the classification used.

Original language	English
Journal	HIV Medicine
DOIs	https://doi.org/10.1111/hiv.13351
Publication status	Published - 24 Jun 2022

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Khuon, D., Rupasinghe, D., Saphonn, V., Kwong, T., Widhani, A., Chaiwarith, R., Ly, P. S., Do, C. D., Avihingsanon, A., Khusuwan, S., Merati, T. P., Van Nguyen, K., Kumarasamy, N., Chan, Y., Azwa, I., Ng, O. T., Kiertiburanakul, S., Tanuma, J., Pujari, S., ... Jiamsakul, A. (2022). BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia‐Pacific region. HIV Medicine. https://doi.org/10.1111/hiv.13351

@article{471ee2ed152c422d86171620ee345b3b,

title = "BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia‐Pacific region",

abstract = "BackgroundNon-Asian body mass index (BMI) classifications are commonly used as a risk factor for high fasting blood glucose (FBG). We investigated the incidence and factors associated with high FBG among people living with HIV in the Asia-Pacific region, using a World Health Organization BMI classification specific to Asian populations.MethodsThis study included people living with HIV enrolled in a longitudinal cohort study from 2003 to 2019, receiving antiretroviral therapy (ART), and without prior tuberculosis. BMI at ART initiation was categorized using Asian BMI classifications: underweight (ResultsA total of 3939 people living with HIV (63% male) were included. In total, 50% had a BMI in the normal weight range, 23% were underweight, 13% were overweight, and 14% were obese. Median age at ART initiation was 34 years (interquartile range 29–41). Overall, 8% had a high FBG, with an incidence rate of 1.14 per 100 person-years. Factors associated with an increased hazard of high FBG included being obese (≥25 kg/m2) compared with normal weight (hazard ratio [HR] = 1.79; 95% confidence interval [CI] 1.31–2.44; p ConclusionPeople living with HIV with BMI >25 kg/m2 were at increased risk of high FBG. This indicates that regular assessments should be performed in those with high BMI, irrespective of the classification used.",

author = "Dyna Khuon and Dhanushi Rupasinghe and Vonthanak Saphonn and Tsz‐shan Kwong and Alvina Widhani and Romanee Chaiwarith and Ly, {Penh Sun} and Do, {Cuong Duy} and Anchalee Avihingsanon and Suwimon Khusuwan and Merati, {Tuti Parwati} and {Van Nguyen}, Kinh and Nagalingeswaran Kumarasamy and Yu‐jiun Chan and Iskandar Azwa and Ng, {Oon Tek} and Sasisopin Kiertiburanakul and Junko Tanuma and Sanjay Pujari and Rossana Ditangco and Fujie Zhang and Choi, {Jun Yong} and Yasmin Gani and Shashikala Sangle and Jeremy Ross and Gorbach, {Pamina M.} and Awachana Jiamsakul",

year = "2022",

month = jun,

day = "24",

doi = "10.1111/hiv.13351",

language = "English",

journal = "HIV Medicine",

issn = "1464-2662",

publisher = "Wiley-Blackwell Publishing Ltd",

}

Khuon, D, Rupasinghe, D, Saphonn, V, Kwong, T, Widhani, A, Chaiwarith, R, Ly, PS, Do, CD, Avihingsanon, A, Khusuwan, S, Merati, TP, Van Nguyen, K, Kumarasamy, N, Chan, Y, Azwa, I, Ng, OT, Kiertiburanakul, S, Tanuma, J, Pujari, S, Ditangco, R, Zhang, F, Choi, JY, Gani, Y, Sangle, S, Ross, J, Gorbach, PM & Jiamsakul, A 2022, 'BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia‐Pacific region', HIV Medicine. https://doi.org/10.1111/hiv.13351

TY - JOUR

T1 - BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia‐Pacific region

AU - Khuon, Dyna

AU - Rupasinghe, Dhanushi

AU - Saphonn, Vonthanak

AU - Kwong, Tsz‐shan

AU - Widhani, Alvina

AU - Chaiwarith, Romanee

AU - Ly, Penh Sun

AU - Do, Cuong Duy

AU - Avihingsanon, Anchalee

AU - Khusuwan, Suwimon

AU - Merati, Tuti Parwati

AU - Van Nguyen, Kinh

AU - Kumarasamy, Nagalingeswaran

AU - Chan, Yu‐jiun

AU - Azwa, Iskandar

AU - Ng, Oon Tek

AU - Kiertiburanakul, Sasisopin

AU - Tanuma, Junko

AU - Pujari, Sanjay

AU - Ditangco, Rossana

AU - Zhang, Fujie

AU - Choi, Jun Yong

AU - Gani, Yasmin

AU - Sangle, Shashikala

AU - Ross, Jeremy

AU - Gorbach, Pamina M.

AU - Jiamsakul, Awachana

PY - 2022/6/24

Y1 - 2022/6/24

N2 - BackgroundNon-Asian body mass index (BMI) classifications are commonly used as a risk factor for high fasting blood glucose (FBG). We investigated the incidence and factors associated with high FBG among people living with HIV in the Asia-Pacific region, using a World Health Organization BMI classification specific to Asian populations.MethodsThis study included people living with HIV enrolled in a longitudinal cohort study from 2003 to 2019, receiving antiretroviral therapy (ART), and without prior tuberculosis. BMI at ART initiation was categorized using Asian BMI classifications: underweight (ResultsA total of 3939 people living with HIV (63% male) were included. In total, 50% had a BMI in the normal weight range, 23% were underweight, 13% were overweight, and 14% were obese. Median age at ART initiation was 34 years (interquartile range 29–41). Overall, 8% had a high FBG, with an incidence rate of 1.14 per 100 person-years. Factors associated with an increased hazard of high FBG included being obese (≥25 kg/m2) compared with normal weight (hazard ratio [HR] = 1.79; 95% confidence interval [CI] 1.31–2.44; p ConclusionPeople living with HIV with BMI >25 kg/m2 were at increased risk of high FBG. This indicates that regular assessments should be performed in those with high BMI, irrespective of the classification used.

AB - BackgroundNon-Asian body mass index (BMI) classifications are commonly used as a risk factor for high fasting blood glucose (FBG). We investigated the incidence and factors associated with high FBG among people living with HIV in the Asia-Pacific region, using a World Health Organization BMI classification specific to Asian populations.MethodsThis study included people living with HIV enrolled in a longitudinal cohort study from 2003 to 2019, receiving antiretroviral therapy (ART), and without prior tuberculosis. BMI at ART initiation was categorized using Asian BMI classifications: underweight (ResultsA total of 3939 people living with HIV (63% male) were included. In total, 50% had a BMI in the normal weight range, 23% were underweight, 13% were overweight, and 14% were obese. Median age at ART initiation was 34 years (interquartile range 29–41). Overall, 8% had a high FBG, with an incidence rate of 1.14 per 100 person-years. Factors associated with an increased hazard of high FBG included being obese (≥25 kg/m2) compared with normal weight (hazard ratio [HR] = 1.79; 95% confidence interval [CI] 1.31–2.44; p ConclusionPeople living with HIV with BMI >25 kg/m2 were at increased risk of high FBG. This indicates that regular assessments should be performed in those with high BMI, irrespective of the classification used.

U2 - 10.1111/hiv.13351

DO - 10.1111/hiv.13351

M3 - Article

SN - 1464-2662

JO - HIV Medicine

JF - HIV Medicine

ER -

BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia‐Pacific region

Abstract

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