Blood leukocyte count on admission predicts cardiovascular events in patients with acute non-st elevation myocardial infarction

Surya Dharma, Rosmarini Hapsari, Bambang Budi Siswanto, Arnoud Van Der Laarse, J. Wouter Jukema

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We aim to test the hypothesis that blood leukocyte count adds prognostic information in patients with acute non-ST-elevation myocardial infarction (non-STEMI). A total of 585 patients with acute non-STEMI (thrombolysis in myocardial infarction risk score≥3) were enrolled in this cohort retrospective study. Blood leukocyte count was measured immediately after admission in the emergency department. The composite of death, reinfarction, urgent revascularization, and stroke during hospitalization were defined as the primary end point of the study. The mean age of the patients was 61±9.6 years and most of them were male (79%). Using multivariate Cox regression analysis involving seven variables (history of smoking, hypertension, heart rate>100 beats/minute, serum creatinine level>1.5 mg/dL, blood leukocyte count>11,000/μL, use of β-blocker, and use of angiotensin-converting enzyme inhibitor), leukocyte count>11,000/μL demonstrated to be a strong predictor of the primary end point (hazard ratio=3.028; 95% confidence interval=1.69-5.40, p<0.001). The high blood leukocyte count on admission is an independent predictor of cardiovascular events in patients with acute non-STEMI.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalInternational Journal of Angiology
Volume24
Issue number2
DOIs
Publication statusPublished - 12 Dec 2014

Keywords

  • acute non-STEMI
  • cardiovascular event
  • leukocyte count
  • predictor

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