TY - JOUR
T1 - Blood Glucose and Glucagon-Like Peptide 1 Level Comparison in Obese Versus Non-Obese Patients
AU - Witjaksono, Fiastuti
AU - Simadibrata, Marcellus
AU - Lukito, Widjaja
AU - Wijaya, Andi
AU - Annisa, Nagita Gianty
N1 - Funding Information:
We would like to acknowledge the Prodia Laboratory for supporting laboratory examination in this study and to Nutrifood Inc. for providing the balanced macronutrient composition formula, and to Ema Sitepu, MD., M.Sc., Ingka Suryo, MD., M.Sc., from the Department of Nutrition, Faculty of Medicine Universitas Indonesia for the help with data collection in this study. The publication of this manuscript is supported by Universitas Indonesia.
Publisher Copyright:
© 2019 Journal of International Dental and Medical Research.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Obesity, a major health concern worldwide, has a pathophysiology related to energy imbalance in the body. Glucagon-like peptide 1 (GLP-1), secreted by L cells of the intestine, acts as a signal for energy balance. GLP-1 is a satiation signal that can promote satiety and reduce food intake. Its secretion is thought to be impaired in obese individuals, causing reduced satiety and hyperphagia. This study was conducted as a clinical trial to determine the effect of breakfast with a balanced macronutrient composition (68.2% carbohydrates, 22.6% lipids, and 12.4% protein) on GLP-1 levels in 22 obese versus 21 non-obese subjects. Blood glucose levels were also evaluated Subjects were provided breakfast, followed by measurement of blood glucose and GLP-1 levels at 0, 15, 60, 120, and 180 minutes after intervention. We found that there are no significant differences between blood glucose levels in obese versus non-obese subjects before or after having breakfast with a balanced macronutrient composition (p > 0.05). There was a significant difference between GLP-1 levels in obese and non-obese subjects at 15 and 60 minutes following intervention (p = 0.042 and p = 0.037, respectively). This finding suggests that there is impairment in postprandial GLP-1 secretion in obese subjects.
AB - Obesity, a major health concern worldwide, has a pathophysiology related to energy imbalance in the body. Glucagon-like peptide 1 (GLP-1), secreted by L cells of the intestine, acts as a signal for energy balance. GLP-1 is a satiation signal that can promote satiety and reduce food intake. Its secretion is thought to be impaired in obese individuals, causing reduced satiety and hyperphagia. This study was conducted as a clinical trial to determine the effect of breakfast with a balanced macronutrient composition (68.2% carbohydrates, 22.6% lipids, and 12.4% protein) on GLP-1 levels in 22 obese versus 21 non-obese subjects. Blood glucose levels were also evaluated Subjects were provided breakfast, followed by measurement of blood glucose and GLP-1 levels at 0, 15, 60, 120, and 180 minutes after intervention. We found that there are no significant differences between blood glucose levels in obese versus non-obese subjects before or after having breakfast with a balanced macronutrient composition (p > 0.05). There was a significant difference between GLP-1 levels in obese and non-obese subjects at 15 and 60 minutes following intervention (p = 0.042 and p = 0.037, respectively). This finding suggests that there is impairment in postprandial GLP-1 secretion in obese subjects.
KW - Blood Glucose
KW - GLP-1
KW - Obese
UR - http://www.scopus.com/inward/record.url?scp=85069436178&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85069436178
SN - 1309-100X
VL - 12
SP - 286
EP - 290
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 1
ER -
