Blood Glucose and Glucagon-Like Peptide 1 Level Comparison in Obese Versus Non-Obese Patients

Fiastuti Witjaksono, Marcellus Simadibrata, Widjaja Lukito, Andi Wijaya, Nagita Gianty Annisa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Obesity, a major health concern worldwide, has a pathophysiology related to energy imbalance in the body. Glucagon-like peptide 1 (GLP-1), secreted by L cells of the intestine, acts as a signal for energy balance. GLP-1 is a satiation signal that can promote satiety and reduce food intake. Its secretion is thought to be impaired in obese individuals, causing reduced satiety and hyperphagia. This study was conducted as a clinical trial to determine the effect of breakfast with a balanced macronutrient composition (68.2% carbohydrates, 22.6% lipids, and 12.4% protein) on GLP-1 levels in 22 obese versus 21 non-obese subjects. Blood glucose levels were also evaluated Subjects were provided breakfast, followed by measurement of blood glucose and GLP-1 levels at 0, 15, 60, 120, and 180 minutes after intervention. We found that there are no significant differences between blood glucose levels in obese versus non-obese subjects before or after having breakfast with a balanced macronutrient composition (p > 0.05). There was a significant difference between GLP-1 levels in obese and non-obese subjects at 15 and 60 minutes following intervention (p = 0.042 and p = 0.037, respectively). This finding suggests that there is impairment in postprandial GLP-1 secretion in obese subjects.

Original languageEnglish
Pages (from-to)286-290
Number of pages5
JournalJournal of International Dental and Medical Research
Issue number1
Publication statusPublished - 1 Jan 2019


  • Blood Glucose
  • GLP-1
  • Obese


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