Birth prevalence and characteristics of congenital cytomegalovirus infection in an urban birth cohort, Jakarta, Indonesia

Nina Dwi Putri, A. Wiyatno, Rama Dhenni, Ida Yus Sriyani, Aghnianditya Kresno Dewantari, S. Handryastuti, Adhi Teguh Perma Iskandar, Meka Medina Rahma, Niphidiah Jumiyanti, Yuni Yudha Aprilia, Ari Prayitno, Mulya Rahma Karyanti, Hindra Irawan Satari, Sri Rezeki Hadinegoro, Khin Saw Aye Myint, Dodi Safari

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objectives: Little is known about the birth prevalence and characteristics of congenital cytomegalovirus (CMV) infection in developing countries. To determine the prevalence and characteristics of congenital CMV infection in Indonesia, we conducted a prospective study in an urban birth cohort of neonates at a national referral hospital in 2016−2017, Jakarta, Indonesia. Methods: Consecutively born neonates were screened for the presence of CMV by using pan-herpesvirus nested-PCR and Sanger sequencing in saliva and/or urine specimens. Both the neonatal clinical findings as well as maternal characteristics were also evaluated. Results: From a total of 411 newborns screened, congenital CMV infection was confirmed in 5.8% of the neonates. These CMV-positive newborns were more likely to have ventriculomegaly and thrombocytopenia compared to CMV-negative neonates. Notably, 67% CMV-positive neonates in our study had clinical findings that required medical intervention, from which only nine presented with symptoms suggestive of congenital CMV infection. Furthermore, congenital CMV infected babies were almost four times more likely to be born to mothers that had placenta previa and placental abruption. Conclusions: Our work highlights the high prevalence of congenital CMV infection in neonates born in one of the biggest referral hospitals in metropolitan Jakarta, Indonesia.

Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalInternational Journal of Infectious Diseases
Volume86
DOIs
Publication statusPublished - 1 Sep 2019

Keywords

  • CMV birth prevalence
  • Congenital anomalies
  • Congenital CMV
  • Cytomegalovirus
  • Indonesia

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