TY - GEN
T1 - Biomarker selection for determining bone biocompatibility of pure magnesium processed by equal channel angular pressing (ECAP) using immunohistochemistry
AU - Handayani, Lisa
AU - Sulistyani, Lilies Dwi
AU - Supriadi, Sugeng
AU - Priosoeryanto, Bambang Pontjo
AU - Latief, Benny Sjarief Sjah
N1 - Publisher Copyright:
© 2018 Author(s). Published by AIP Publishing.
PY - 2018/2/13
Y1 - 2018/2/13
N2 - Since grain refinement is proved to be favorable to improve mechanical properties and corrosion resistance, a new conceptual metal forming process, equal channel angular pressing (ECAP), has been carried out on magnesium, a very promising biodegradable material in the field of oral and maxillofacial surgery. The popularity of immunohisto-chemistry (IHC) has been rising following the discovery of biomarker. In the meantime, more antibodies being produced for research have been continuously rising and becoming more varied. This review provides a conceptual framework to understand the roles of IHC on determination of bone biocompatibility to ECAP magnesium by selecting biomarker and point needed to either select or make an antibody to the target. From the review, it has been concluded that the most suitable biomarkers for biocompatibility test of bone implanted with ECAP magnesium are collagen-1, osteocalcin, smooth muscle actin, and CD68.
AB - Since grain refinement is proved to be favorable to improve mechanical properties and corrosion resistance, a new conceptual metal forming process, equal channel angular pressing (ECAP), has been carried out on magnesium, a very promising biodegradable material in the field of oral and maxillofacial surgery. The popularity of immunohisto-chemistry (IHC) has been rising following the discovery of biomarker. In the meantime, more antibodies being produced for research have been continuously rising and becoming more varied. This review provides a conceptual framework to understand the roles of IHC on determination of bone biocompatibility to ECAP magnesium by selecting biomarker and point needed to either select or make an antibody to the target. From the review, it has been concluded that the most suitable biomarkers for biocompatibility test of bone implanted with ECAP magnesium are collagen-1, osteocalcin, smooth muscle actin, and CD68.
KW - Biocompatibility
KW - Biodegradable
KW - Biomarker
KW - Bone
KW - ECAP
KW - Immunohistochemistry; Magnesium
UR - http://www.scopus.com/inward/record.url?scp=85042389311&partnerID=8YFLogxK
U2 - 10.1063/1.5023945
DO - 10.1063/1.5023945
M3 - Conference contribution
AN - SCOPUS:85042389311
T3 - AIP Conference Proceedings
BT - 2nd Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Dhelika, Radon
A2 - Whulanza, Yudan
A2 - Ramahdita, Ghiska
A2 - Wulan, Praswasti P.D.K.
PB - American Institute of Physics Inc.
T2 - 2nd Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2017
Y2 - 25 July 2017 through 26 July 2017
ER -