TY - JOUR
T1 - BIOLOGICAL ACTIVITIES OF EXTRACTS AND SECONDARY METABOLITE OF Macaranga mappa BARK AS AN ANTIDIABETIC BY α-GLUCOSIDASE INHIBITOR, ANTIOXIDANT, AND CYTOTOXICITY
AU - Cahyana, Antonius Herry
AU - Liandi, Agus Rimus
AU - Wicaksono, Syukur Sakban
AU - Darmawan, Akhmad
N1 - Funding Information:
This research was funded by the Ministry of Education, Culture, Research, and Technology through the "Hibah Publikasi Terindeks International (PUTI) Q2" research grant No. NKB-642/UN2.RST/HKP.05.00/2022.
Publisher Copyright:
© 2023, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - The biological activities of extracts and isolated compounds of Macaranga mappa stem bark for antidiabetic herbal medicine, antioxidant, and cytotoxicity activities have been determined. The antidiabetic, antioxidant, and cytotoxicity activities of the sample were carried out by inhibition value of α-glucosidase, DPPH method, and brine shrimp larvae method, respectively. The initial methanol extract and its fractions have good activities against antidiabetics and antioxidants, except for the hexane fraction. The fractions with the highest activity for the antidiabetic and antioxidant tests were the water fraction IC50 6.654 ppm and the butanol fraction IC50 32.34 ppm, respectively. The toxicity test results with the BSLT method showed that all fractions were non-toxic LC50>1000 ppm. The isolated compound from the ethyl acetate fraction was a coumarin derivative, namely scopoletin, with antidiabetic and antioxidant activities.
AB - The biological activities of extracts and isolated compounds of Macaranga mappa stem bark for antidiabetic herbal medicine, antioxidant, and cytotoxicity activities have been determined. The antidiabetic, antioxidant, and cytotoxicity activities of the sample were carried out by inhibition value of α-glucosidase, DPPH method, and brine shrimp larvae method, respectively. The initial methanol extract and its fractions have good activities against antidiabetics and antioxidants, except for the hexane fraction. The fractions with the highest activity for the antidiabetic and antioxidant tests were the water fraction IC50 6.654 ppm and the butanol fraction IC50 32.34 ppm, respectively. The toxicity test results with the BSLT method showed that all fractions were non-toxic LC50>1000 ppm. The isolated compound from the ethyl acetate fraction was a coumarin derivative, namely scopoletin, with antidiabetic and antioxidant activities.
KW - Antidiabetic
KW - Antioxidant
KW - Biological Activity
KW - Macaranga mappa
KW - Secondary Metabolite
KW - α-glucosidase Inhibitor
UR - http://www.scopus.com/inward/record.url?scp=85150824836&partnerID=8YFLogxK
U2 - 10.31788/RJC.2023.1618029
DO - 10.31788/RJC.2023.1618029
M3 - Article
AN - SCOPUS:85150824836
SN - 0974-1496
VL - 16
SP - 290
EP - 296
JO - Rasayan Journal of Chemistry
JF - Rasayan Journal of Chemistry
IS - 1
ER -