TY - JOUR
T1 - Biochip array technology for morphine and benzodiazepine testing in urine of patients undertaking methadone maintenance therapy program
AU - Sawitri, R.
AU - Sampurna, B.
AU - Sugiharto, A. F.
N1 - Publisher Copyright:
© 2018 Institute of Physics Publishing. All rights reserved.
PY - 2018/9/7
Y1 - 2018/9/7
N2 - Forensic toxicology test includes a qualitative and quantitative test. Biochip array technology (BAT) is a new nanotechnological method employed in forensic toxicology. This study aimed to determine the effectiveness of BAT test in forensic toxicology of morphine and benzodiazepine in urine samples. This cross-sectional diagnostic study was applied to 20 patients aged > 18 years in August 2014 at the primary health centers at Johar Baru, Jakarta Pusat. Gas chromatography (GC)/mass spectrometry (MS) of these samples identified four samples as morphine positive and three as benzodiazepine positive. BAT test identified four samples as morphine positive and six as benzodiazepine positive. Diagnostic analysis of morphine testing confirmed that BAT test showed 100% sensitivity, 100% specificity, 100% positive predictive value, and 100% negative predictive value. On the other hand, diagnostic test analysis of benzodiazepine testing confirmed that BAT test showed 100% sensitive, 82.35% specific, 50% positive predictive value, and 100% negative predictive value. Therefore, BAT test is reliable for morphine testing but only when the sample is controlled; however, it is unreliable for benzodiazepine testing.
AB - Forensic toxicology test includes a qualitative and quantitative test. Biochip array technology (BAT) is a new nanotechnological method employed in forensic toxicology. This study aimed to determine the effectiveness of BAT test in forensic toxicology of morphine and benzodiazepine in urine samples. This cross-sectional diagnostic study was applied to 20 patients aged > 18 years in August 2014 at the primary health centers at Johar Baru, Jakarta Pusat. Gas chromatography (GC)/mass spectrometry (MS) of these samples identified four samples as morphine positive and three as benzodiazepine positive. BAT test identified four samples as morphine positive and six as benzodiazepine positive. Diagnostic analysis of morphine testing confirmed that BAT test showed 100% sensitivity, 100% specificity, 100% positive predictive value, and 100% negative predictive value. On the other hand, diagnostic test analysis of benzodiazepine testing confirmed that BAT test showed 100% sensitive, 82.35% specific, 50% positive predictive value, and 100% negative predictive value. Therefore, BAT test is reliable for morphine testing but only when the sample is controlled; however, it is unreliable for benzodiazepine testing.
UR - http://www.scopus.com/inward/record.url?scp=85054483553&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/1073/4/042024
DO - 10.1088/1742-6596/1073/4/042024
M3 - Conference article
AN - SCOPUS:85054483553
SN - 1742-6588
VL - 1073
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
IS - 4
M1 - 042024
T2 - 2nd Physics and Technologies in Medicine and Dentistry Symposium, PTMDS 2018
Y2 - 18 July 2018 through 18 July 2018
ER -