Biochip array technology for morphine and benzodiazepine testing in urine of patients undertaking methadone maintenance therapy program

R. Sawitri, Budi Sampurna, A. F. Sugiharto

Research output: Contribution to journalConference articlepeer-review

Abstract

Forensic toxicology test includes a qualitative and quantitative test. Biochip array technology (BAT) is a new nanotechnological method employed in forensic toxicology. This study aimed to determine the effectiveness of BAT test in forensic toxicology of morphine and benzodiazepine in urine samples. This cross-sectional diagnostic study was applied to 20 patients aged > 18 years in August 2014 at the primary health centers at Johar Baru, Jakarta Pusat. Gas chromatography (GC)/mass spectrometry (MS) of these samples identified four samples as morphine positive and three as benzodiazepine positive. BAT test identified four samples as morphine positive and six as benzodiazepine positive. Diagnostic analysis of morphine testing confirmed that BAT test showed 100% sensitivity, 100% specificity, 100% positive predictive value, and 100% negative predictive value. On the other hand, diagnostic test analysis of benzodiazepine testing confirmed that BAT test showed 100% sensitive, 82.35% specific, 50% positive predictive value, and 100% negative predictive value. Therefore, BAT test is reliable for morphine testing but only when the sample is controlled; however, it is unreliable for benzodiazepine testing.

Original languageEnglish
Article number042024
JournalJournal of Physics: Conference Series
Volume1073
Issue number4
DOIs
Publication statusPublished - 7 Sep 2018
Event2nd Physics and Technologies in Medicine and Dentistry Symposium, PTMDS 2018 - Depok, West Java, Indonesia
Duration: 18 Jul 201818 Jul 2018

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