Bioactive compounds screening from Zingiberaceae family as influenza a/swine flu virus neuraminidase inhibitor through docking approach

Usman Sumo Friend, Fadilah, Arli Aditya Parikesit

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Problem statement: Influenza A/H1N1 is a disease caused by infection of influenza a virus subtype H1N1. It is a major health problem in tropical and subtropical countries. This virus constantly mutates and consequently will be developed into new drug-resistant strains. Approach: In this research, we have conducted docking study to screen bioactive compounds from Zingiberaceae family, which has a role as neuraminidase inhibitor of influenza a virus. Results: The docking result identified that 1, 2-di-O- β-D-glucopyranosyl-4-allylbenzene (BGA) compound has the affinity and ability to inhibit neuraminidase. There are fourteen residues contact of BGA compound to neuraminidase and eight residues contact of enzyme that formed hydrogen bond with catalytic site. Conclusion/recommendation: The docking result showed that BGA has better binding energy and affinity compared with other bioactive compounds and the standard compounds.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalOnLine Journal of Biological Sciences
Volume10
Issue number4
Publication statusPublished - 1 Jan 2010

Keywords

  • Bioactive compounds
  • Catalytic site
  • Conducted docking study
  • Hydrogen bond
  • Influenza A/H1N1
  • Initial screening process
  • Molecular docking
  • Neuraminidase inhibitor
  • Neuraminidase inhibitory
  • Screen bioactive
  • Subtropical countries
  • Surface glycoprotein
  • β-d-glucopyranosyl-4-allylbenzene (BGA)

Fingerprint

Dive into the research topics of 'Bioactive compounds screening from Zingiberaceae family as influenza a/swine flu virus neuraminidase inhibitor through docking approach'. Together they form a unique fingerprint.

Cite this