TY - JOUR
T1 - BIOACTIVE COMPOUNDS OF FLAVONE DIMERS FROM INDONESIAN Araucaria columnaris LEAVES
AU - Kurniawanti,
AU - Agusta, D. D.
AU - Sugita, P.
AU - Suparto, I. H.
AU - Dianhar, H.
AU - Rahayu, D. U.C.
N1 - Publisher Copyright:
© 2023, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.
PY - 2023/7/1
Y1 - 2023/7/1
N2 - This study aimed to isolate the flavone dimers in the acetone extract of Araucaria columnaris leaves and evaluate their potential biological activities. Three flavone dimers, 1-3, were isolated and identified by spectroscopic analysis using UV, IR, NMR, and mass spectrometry. The acetone extract and isolated metabolites were examined for their antiangiogenic activity against the Calf Pulmonary Arterial Endothelial (CPAE) cell and antioxidant performance using 2,2-diphenyl-1-picrylhydrazyl (DPPH). The results showed that 4',4'",7,7"-tetra-O-methylcupressuflavone (1) and acetone extract had IC50 values of 272.95±7.05 and 239.36±13.50 μg/mL, respectively, against CPAE cell. The other two isolated metabolites, 4',7,7"-tri-O-methylcupressuflavone (2) and 4"',7-di-O-methylcupressuflavone (3), showed high activity with IC50 values of 39.5±1.44 and 66.13±15.96 μg/mL, respectively. Although none of the individual components demonstrated any detectable antioxidant activity (IC50 > 100 μg/mL), the acetone extract showed moderate antioxidant activity with an IC50 value of 69.2 μg/mL.
AB - This study aimed to isolate the flavone dimers in the acetone extract of Araucaria columnaris leaves and evaluate their potential biological activities. Three flavone dimers, 1-3, were isolated and identified by spectroscopic analysis using UV, IR, NMR, and mass spectrometry. The acetone extract and isolated metabolites were examined for their antiangiogenic activity against the Calf Pulmonary Arterial Endothelial (CPAE) cell and antioxidant performance using 2,2-diphenyl-1-picrylhydrazyl (DPPH). The results showed that 4',4'",7,7"-tetra-O-methylcupressuflavone (1) and acetone extract had IC50 values of 272.95±7.05 and 239.36±13.50 μg/mL, respectively, against CPAE cell. The other two isolated metabolites, 4',7,7"-tri-O-methylcupressuflavone (2) and 4"',7-di-O-methylcupressuflavone (3), showed high activity with IC50 values of 39.5±1.44 and 66.13±15.96 μg/mL, respectively. Although none of the individual components demonstrated any detectable antioxidant activity (IC50 > 100 μg/mL), the acetone extract showed moderate antioxidant activity with an IC50 value of 69.2 μg/mL.
KW - Antiangiogenic
KW - Antioxidant Activity
KW - Araucaria columnaris
KW - Biflavonoids
KW - CPAE Cell
UR - http://www.scopus.com/inward/record.url?scp=85182485565&partnerID=8YFLogxK
U2 - 10.31788/RJC.2023.1638390
DO - 10.31788/RJC.2023.1638390
M3 - Article
AN - SCOPUS:85182485565
SN - 0974-1496
VL - 16
SP - 1872
EP - 1882
JO - Rasayan Journal of Chemistry
JF - Rasayan Journal of Chemistry
IS - 3
ER -