Compression still become main concern in big data framework. The performance of big data depend on speed of data transfer. Compressed data can speed up transfer data between network. It also save more space for storage. Several compression method is provide by Hadoop as a most common big data framework. That method mostly for general purpose. But the performance still have to optimize especially for Biomedical record like ECG data. We propose Set Partitioning in Hierarchical Tree (SPIHT) for big data compression with study case ECG signal data. In this paper compression will run in Hadoop Framework. The proposed method has stages such as input signal, map input signal, spiht coding, and reduce bit-stream. The compression produce compressed data for intermediate (Map) output and final (reduce) output. The experiment using ECG data to measure compression performance. The proposed method gets Percentage Root-mean-square difference (PRD) is about 1.0. Compare to existing method, the proposed method get better Compression Ratio (CR) with competitive longer compression time. So proposed method gets better performance compare to other method especially for ECG dataset.