Beneficial effect of food substitute containing L-arginine, ω-3 poly unsaturated fatty acid, and ribonucleic acid in preventing or improving metabolic syndrome: A study in 15 overweight patients and a study of fatty acid metabolism in animals

Kenichi Watanabe, Wawaimuli Arozal, Hiroko Tanaka, Meilei Ma, Susumu Satoh, Punniyakoti T. Veeraveedu, Takashi Kobayashi, Hiroshi Oyama, Yoshiko Sakaguchi

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1 Citation (Scopus)

Abstract

This study was conducted to investigate whether or not a food substitute (Dr. BAANs®) containing three bioactive components L-arginine, ω-3 polyunsaturated fatty acid, and ribonucleic acid, supplied orally to 15 overweight patients, may have efficacy to prevent or improve the metabolic syndrome of these patients. To provide supporting data for this clinical study, the in vivo fatty acid metabolism of obese mice was analyzed using 125I labeled 15-(p-iodophenyl)-9-methylpentadecanoic acid (9MPA) in the tissues' lipid pool. After 3 months of intervention, the results showed that there were improvements observed in liver functions, lipid profiles and metabolic syndrome marker. Significant differences were also found in the values of blood pressure, body weight, percentage of body fat, and body mass index. In the animal study, the tissue uptake of 125I-9MPA at 10 min after injection was higher in obese mice than in the control mice and the treatment with Dr. BAANs® in obese mice decreased the uptake significantly. The final product metabolite of p-iodophenylacetic acid in obese mice was increased significantly by the treatment. In conclusion, this food substitute may have a beneficial effect for the prevention or improvement of metabolic syndrome.

Original languageEnglish
Pages (from-to)266-274
Number of pages9
JournalJournal of Clinical Biochemistry and Nutrition
Volume44
Issue number3
DOIs
Publication statusPublished - 1 May 2009

Keywords

  • ω-3 poly unsaturated fatty acid
  • Fatty acid metabolism
  • L-arginine
  • Metabolic syndrome
  • Ribonucleic acid

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