Abstract
Saurauia vulcani flora develops certainly in North Sumatra Province, Indonesia. It is normally consumed as an antidiabetic remedy and a treatment related to digestion diseases. This research aims to isolate the major compound from S. vulcani plants and assess the bioactivity of the S. vulcani plant for its anti-colorectal cancer potential. Subsequently, the ethyl acetate fraction was analyzed with a solvent system used as the eluent ethyl acetate: methanol: Aquadest = 4.6:0.2:0.2. Utilizing spectroscopy, we determined the chemical structure of the remote substance. Utilizing the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide technique in vitro, the anti-colorectal cancer activity was demonstrated against WiDr cancer cells. This study revealed that the major compound was identified as avicularin. The avicularin compound is a flavonoid group known to have anticancer activity. The cytotoxicity of avicularin compound was assessed against the WiDr cell line, with a 50% inhibition concentration value of 521.14 μg/ml. The bioactivity of the ethyl acetate fraction is stronger than that of the isolated part (avicularin compound).
| Original language | English |
|---|---|
| Pages (from-to) | 101-110 |
| Number of pages | 10 |
| Journal | Journal of Applied Pharmaceutical Science |
| Volume | 13 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2023 |
Keywords
- avicularin
- colorectal cancer
- extract
- plant leaves
- Saurauia vulcani
