There is a continuous increase in the number of COVID-19 cases in Indonesia. To control its spread, the government has implemented several strategies, such as policies associated with large-scale social restrictions (Indonesian: Pembatasan Sosial Berskala Besar or PSBB). The purpose of this study is to determine the variables that influence attitudes toward PSBB policies in Indonesia. This is a cross-sectional study with data obtained from 856 respondents from all provinces in Indonesia using the partial least squares and structural equation model (PLS-SEM). A total of 23 indicators were used to examine these policies, which were grouped into five variables: benefits of the PSBB (5 indicators), positive perception (5 indicators), negative perception (3 indicators), threatened perceptions of COVID-19 (5 indicators), and attitude toward the PSBB policy (5 indicators). The model explains over 50% of attitudes exhibited toward PSBB policy implementation and how it is influenced by the perceived benefits, negative and positive perceptions as well as the threat associated with COVID-19. The policy of stay at home, physical distancing, and always using face masks needs to be continued for the public to have a supportive attitude of the PSBB policy in preventing the transmission of COVID-19.