Association of vascular endothelial growth factor gene +405 C>G and -460 C>T polymorphism with diabetic foot ulcer in Indonesia

Kemas Muhammad Dahlan, Dedy Pratama, Akhmadu Muradi, Dwi Anita Suryandari, Luluk Yunaini, Setyawati Boediningsih

Research output: Contribution to journalConference articlepeer-review

Abstract

Background, the greatest risk factor for Diabetic foot ulcer (DFU) is neuropathy. Vascular endothelial growth factor (VEGF) gene is a gene encodes a protein vascular endothelial growth factor (VEGF), which has a function of angiogenesis and neurogenesis. VEGF plays a role in neuropathy, angiopathy and wound healing in DFU. Methods: Case-control study, case is types 2 DM with DFU and control is type 2 DM without DFU, Polymerase Chain Reaction-Restriction Fragment length polymorphism was done to find genotype polymorphism of VEGF gene. Results: Genotype GG VEGF + 405C> G does not have a significant association with DFU in DM patients (GG + CG / CC; OR; 0.52, 95% CI; 0.15 to 1.73 p; 0.289). G allele is proposed as a protective factor in DFU (OR; 0.86, 95% CI 0.57 to 1.28, and p; 0.456). Genotype TT from VEGF gene -460 C> T; have no significant association with DFU (TT + CT / CC; OR; 0.97, 95% CI; 0.41 to 2.26 and p; 0.942). T allele is predicted as protective factor in DFU (OR; 0.90, 95% CI; 0.59 to 1.37 and p; 0,641). Conclusion: G alleles and T alleles are predicted as a protective factor in DM patients associated with DFU.

Original languageEnglish
Article number012008
JournalJournal of Physics: Conference Series
Volume1246
Issue number1
DOIs
Publication statusPublished - 15 Jul 2019
Event1st Sriwijaya International Conference on Medical Sciences, SICMS 2018 - Palembang, South Sumatra, Indonesia
Duration: 26 Oct 201827 Oct 2018

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