Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia

Sibylle G. Schwab, Aaaa Kusumawardhani, Nan Dai, Wen Wen Qin, Mutiara D.B. Wildenauer, Feranindhya Agiananda, Nurmiati Amir, Ronald Antoni, Tiana Arsianti, Asmarahadi Asmarahadi, Hervita Diatri, Prianto Djatmiko, Irmansyah Irmansyah, Siti Khalimah, Irmia Kusumadewi, Profitasari Kusumaningrum, Petrin Redayani Lukman, Lukman Mustar, Martina W Nasrun, Safyuni NaswatiPrasetiyawan Prasetiyawan, Gerald M. Semen, Kristiana Siste, Heriani, Natalia Widiasih, Tjhin Wiguna, Widayanti Dewi Wulandari, Beben Benyamin, Dieter B. Wildenauer

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Association of rs1344706 in the ZNF804A gene (2q32.1) with schizophrenia was first reported in a genome wide scan conducted in a sample of 479 cases and replicated in 6666 cases. Subsequently, evidence by replication was obtained in several samples with European- and Asian ancestral background. Methods: We report ascertainment, clinical characterization, quality control, and determination of ancestral background of a case control sample from Indonesia, comprising 1067 cases and 1111 ancestry matched controls. Genotyping was performed using a fluorescence-based allelic discrimination assay (TaqMan SNP genotyping assay) and a newly designed PCR-RFLP assay for confirmation of rs1344706 genotypes. Results: We confirmed association of the T-allele of rs1344706 with schizophrenia in a newly ascertained sample from Indonesia with Southeast Asian ancestral background (P = 0.019, OR = 1.155, 95%, CI 1.025-1.301). In addition, we studied several SNPs in the vicinity of rs1344706, for which nominally significant results had been reported. None of the association P values of the additional SNPs exceeded that of rs1344706. Conclusion: We provide additional evidence for association of the ZNF804A gene with schizophrenia. We conclude that rs1344706 or a yet unknown polymorphism in linkage disequilibrium is also involved in conferring susceptibility to schizophrenia in samples with different (Asian) ancestral backgrounds.

Original languageEnglish
Pages (from-to)46-52
Number of pages7
JournalSchizophrenia Research
Volume147
Issue number1
DOIs
Publication statusPublished - 1 Jun 2013

Keywords

  • Asian ancestral background
  • Association study
  • Indonesian population
  • Replication
  • Schizophrenia
  • Zinc finger protein ZNF804A

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    Schwab, S. G., Kusumawardhani, A., Dai, N., Qin, W. W., Wildenauer, M. D. B., Agiananda, F., Amir, N., Antoni, R., Arsianti, T., Asmarahadi, A., Diatri, H., Djatmiko, P., Irmansyah, I., Khalimah, S., Kusumadewi, I., Kusumaningrum, P., Lukman, P. R., Mustar, L., Nasrun, M. W., ... Wildenauer, D. B. (2013). Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia. Schizophrenia Research, 147(1), 46-52. https://doi.org/10.1016/j.schres.2013.03.022