TY - JOUR
T1 - Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia
AU - Schwab, Sibylle G.
AU - Kusumawardhani, Aaaa
AU - Dai, Nan
AU - Qin, Wen Wen
AU - Wildenauer, Mutiara D.B.
AU - Agiananda, Feranindhya
AU - Amir, Nurmiati
AU - Antoni, Ronald
AU - Arsianti, Tiana
AU - Asmarahadi, Asmarahadi
AU - Diatri, Hervita
AU - Djatmiko, Prianto
AU - Irmansyah, Irmansyah
AU - Khalimah, Siti
AU - Kusumadewi, Irmia
AU - Kusumaningrum, Profitasari
AU - Lukman, Petrin Redayani
AU - Mustar, Lukman
AU - Nasrun, Martina W
AU - Naswati, Safyuni
AU - Prasetiyawan, Prasetiyawan
AU - Semen, Gerald M.
AU - Siste, Kristiana
AU - Heriani, null
AU - Widiasih, Natalia
AU - Wiguna, Tjhin
AU - Wulandari, Widayanti Dewi
AU - Benyamin, Beben
AU - Wildenauer, Dieter B.
N1 - Funding Information:
Funding for this work was provided by the National Health Medical Research Council (NHMRC project grant #513861 to DBW and SGS). NHMRC had no further role in the study design, in the collection and interpretation of data, in the writing of the manuscript, and in the decision to submit the paper for publication.
Funding Information:
We are grateful to all patients and control individuals who participated in these studies as well as to the clinic directors, clinicians, nurses and caretakers who assisted in recruitment of this sample. Support from NHMRC (project grant # 513861 to DBW and SGS) is acknowledged.
PY - 2013/6
Y1 - 2013/6
N2 - Background: Association of rs1344706 in the ZNF804A gene (2q32.1) with schizophrenia was first reported in a genome wide scan conducted in a sample of 479 cases and replicated in 6666 cases. Subsequently, evidence by replication was obtained in several samples with European- and Asian ancestral background. Methods: We report ascertainment, clinical characterization, quality control, and determination of ancestral background of a case control sample from Indonesia, comprising 1067 cases and 1111 ancestry matched controls. Genotyping was performed using a fluorescence-based allelic discrimination assay (TaqMan SNP genotyping assay) and a newly designed PCR-RFLP assay for confirmation of rs1344706 genotypes. Results: We confirmed association of the T-allele of rs1344706 with schizophrenia in a newly ascertained sample from Indonesia with Southeast Asian ancestral background (P = 0.019, OR = 1.155, 95%, CI 1.025-1.301). In addition, we studied several SNPs in the vicinity of rs1344706, for which nominally significant results had been reported. None of the association P values of the additional SNPs exceeded that of rs1344706. Conclusion: We provide additional evidence for association of the ZNF804A gene with schizophrenia. We conclude that rs1344706 or a yet unknown polymorphism in linkage disequilibrium is also involved in conferring susceptibility to schizophrenia in samples with different (Asian) ancestral backgrounds.
AB - Background: Association of rs1344706 in the ZNF804A gene (2q32.1) with schizophrenia was first reported in a genome wide scan conducted in a sample of 479 cases and replicated in 6666 cases. Subsequently, evidence by replication was obtained in several samples with European- and Asian ancestral background. Methods: We report ascertainment, clinical characterization, quality control, and determination of ancestral background of a case control sample from Indonesia, comprising 1067 cases and 1111 ancestry matched controls. Genotyping was performed using a fluorescence-based allelic discrimination assay (TaqMan SNP genotyping assay) and a newly designed PCR-RFLP assay for confirmation of rs1344706 genotypes. Results: We confirmed association of the T-allele of rs1344706 with schizophrenia in a newly ascertained sample from Indonesia with Southeast Asian ancestral background (P = 0.019, OR = 1.155, 95%, CI 1.025-1.301). In addition, we studied several SNPs in the vicinity of rs1344706, for which nominally significant results had been reported. None of the association P values of the additional SNPs exceeded that of rs1344706. Conclusion: We provide additional evidence for association of the ZNF804A gene with schizophrenia. We conclude that rs1344706 or a yet unknown polymorphism in linkage disequilibrium is also involved in conferring susceptibility to schizophrenia in samples with different (Asian) ancestral backgrounds.
KW - Asian ancestral background
KW - Association study
KW - Indonesian population
KW - Replication
KW - Schizophrenia
KW - Zinc finger protein ZNF804A
UR - http://www.scopus.com/inward/record.url?scp=84877105082&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2013.03.022
DO - 10.1016/j.schres.2013.03.022
M3 - Article
C2 - 23590871
AN - SCOPUS:84877105082
SN - 0920-9964
VL - 147
SP - 46
EP - 52
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1
ER -
