Association of progesterone receptor gene polymorphisms in promoter region with ovarian endometriosis in Indonesian women

Asmarinah, Ririn Rahmala Febri, Adita Hadining Putri, Aisyah Rifani, R. Muharam

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Endometriosis is a common condition that can cause pain and infertility in women, defined as the presence of endometrial tissue outside the uterus. Characterized by the growth of endometrial tissue implants in ectopic sites, endometriosis has been suggested to have a genetic basis because of its marked familial tendency. Here we investigated in Indonesian women the association of ovarian endometriosis and single nucleotide polymorphisms (SNP) in progesterone receptor (PGR) gene. Methods: This research is a case-control study comparing 25 women with ovarian endometriosis and 21 women without endometriosis. Sequencing was used to determined polymorphisms in PGR gene. Statistical analysis was Chi-square test, a two-tailed p value less than 0,05 was considered significant. Result: We found a statistically significant difference in the distribution of PGR genotypes rs10895068 between patients with ovarian endometriosis and controls (p = 0, 019). In the other hand, there was no association between allele G and A and ovarian endometriosis (p > 0, 05, OR = 0,428). Conclusion: These finding suggest that the genetic variants of PGR gene may contribute to the risk of endometriosis.

Original languageEnglish
Pages (from-to)6909-6911
Number of pages3
JournalAdvanced Science Letters
Volume23
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Endometriosis
  • Polymorphisms
  • Progesterone Receptor

Fingerprint

Dive into the research topics of 'Association of progesterone receptor gene polymorphisms in promoter region with ovarian endometriosis in Indonesian women'. Together they form a unique fingerprint.

Cite this