TY - JOUR
T1 - Association between XRCC3 gene polymorphism and the risk of head and neck squamous cell carcinoma
AU - Listyowati,
AU - Viola, Amanda
AU - Midoen, Yunardi Hanafi
AU - Gultom, Ferry Pergamus
AU - Suryandari, Dwi Anita
AU - Auerkari, Elza Ibrahim
N1 - Funding Information:
We would like to thank Indonesian Ministry of Research, Technology and Higher Education through to University of Indonesia (EIA, Grant number 569/UN2. R3.1/HKP.05.00/2017-2018) as a financial support.
Publisher Copyright:
© University of Dicle.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Capacity for DNA repair is essential in maintaining human cellular functions and homeostasis. Repair capacity can be altered by XRCC3 gene polymorphisms that affect an individual's susceptibility to carcinogenesis. The present study aimed to investigate the potential association between the XRCC3 C722T (rs861539) gene polymorphism and the risk of head and neck squamous cell carcinoma (HNSCC) in an Indonesian population. Using the polymerase chain reaction-restriction fragment length polymorphism method, the genomic DNA of 81 patients with oral squamous cell carcinoma and 95 healthy control participants was genotyped to identify the status of XRCC3 C722T polymorphism. For statistical analysis, chi-square test was applied. The TT genotype and T allele of the XRCC3 C722T polymorphism was significantly associated with the risk of HNSCC (P=0.001). The C722T (rs861539) polymorphism of the XRCC3 gene may be associated with the risk of HNSCC. Moreover, this polymorphism might be used as a predictive indicator of precancerous lesions and HNSCC in an Indonesian population.
AB - Capacity for DNA repair is essential in maintaining human cellular functions and homeostasis. Repair capacity can be altered by XRCC3 gene polymorphisms that affect an individual's susceptibility to carcinogenesis. The present study aimed to investigate the potential association between the XRCC3 C722T (rs861539) gene polymorphism and the risk of head and neck squamous cell carcinoma (HNSCC) in an Indonesian population. Using the polymerase chain reaction-restriction fragment length polymorphism method, the genomic DNA of 81 patients with oral squamous cell carcinoma and 95 healthy control participants was genotyped to identify the status of XRCC3 C722T polymorphism. For statistical analysis, chi-square test was applied. The TT genotype and T allele of the XRCC3 C722T polymorphism was significantly associated with the risk of HNSCC (P=0.001). The C722T (rs861539) polymorphism of the XRCC3 gene may be associated with the risk of HNSCC. Moreover, this polymorphism might be used as a predictive indicator of precancerous lesions and HNSCC in an Indonesian population.
KW - Association study
KW - DNA repair
KW - Gene polymorphism
KW - Head and neck squamous cell carcinoma
KW - XRCC3
UR - http://www.scopus.com/inward/record.url?scp=85081277830&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85081277830
SN - 1309-100X
SP - 1686
EP - 1689
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 4
ER -
