Capacity for DNA repair is essential in maintaining human cellular functions and homeostasis. Repair capacity can be altered by XRCC3 gene polymorphisms that affect an individual's susceptibility to carcinogenesis. The present study aimed to investigate the potential association between the XRCC3 C722T (rs861539) gene polymorphism and the risk of head and neck squamous cell carcinoma (HNSCC) in an Indonesian population. Using the polymerase chain reaction-restriction fragment length polymorphism method, the genomic DNA of 81 patients with oral squamous cell carcinoma and 95 healthy control participants was genotyped to identify the status of XRCC3 C722T polymorphism. For statistical analysis, chi-square test was applied. The TT genotype and T allele of the XRCC3 C722T polymorphism was significantly associated with the risk of HNSCC (P=0.001). The C722T (rs861539) polymorphism of the XRCC3 gene may be associated with the risk of HNSCC. Moreover, this polymorphism might be used as a predictive indicator of precancerous lesions and HNSCC in an Indonesian population.
|Number of pages||4|
|Journal||Journal of International Dental and Medical Research|
|Publication status||Published - 1 Jan 2019|
- Association study
- DNA repair
- Gene polymorphism
- Head and neck squamous cell carcinoma