Association between XRCC3 gene polymorphism and the risk of head and neck squamous cell carcinoma

Listyowati, Amanda Viola, Yunardi Hanafi Midoen, Ferry Pergamus Gultom, Dwi Anita Suryandari, Elza Ibrahim Auerkari

Research output: Contribution to journalArticle

Abstract

Capacity for DNA repair is essential in maintaining human cellular functions and homeostasis. Repair capacity can be altered by XRCC3 gene polymorphisms that affect an individual's susceptibility to carcinogenesis. The present study aimed to investigate the potential association between the XRCC3 C722T (rs861539) gene polymorphism and the risk of head and neck squamous cell carcinoma (HNSCC) in an Indonesian population. Using the polymerase chain reaction-restriction fragment length polymorphism method, the genomic DNA of 81 patients with oral squamous cell carcinoma and 95 healthy control participants was genotyped to identify the status of XRCC3 C722T polymorphism. For statistical analysis, chi-square test was applied. The TT genotype and T allele of the XRCC3 C722T polymorphism was significantly associated with the risk of HNSCC (P=0.001). The C722T (rs861539) polymorphism of the XRCC3 gene may be associated with the risk of HNSCC. Moreover, this polymorphism might be used as a predictive indicator of precancerous lesions and HNSCC in an Indonesian population.

Original languageEnglish
Pages (from-to)1686-1689
Number of pages4
JournalJournal of International Dental and Medical Research
Issue number4
Publication statusPublished - 1 Jan 2019

Keywords

  • Association study
  • DNA repair
  • Gene polymorphism
  • Head and neck squamous cell carcinoma
  • XRCC3

Fingerprint Dive into the research topics of 'Association between XRCC3 gene polymorphism and the risk of head and neck squamous cell carcinoma'. Together they form a unique fingerprint.

  • Cite this