Association between Volatile Sulfur Compounds Prevotella intermedi a and Matrix Metalloproteinase-8 Expression

Fergy Christin Maitimu, Yuniarti Soeroso, Hari Sunarto, Boy Muchlis Bachtiar

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1 Citation (Scopus)


Objective: To determine the correlation between levels of methyl mercaptan (CH3SH) hydrogen sulfide (H2S), the proportion of Prevotella intermedia (Pi), and matrix metalloproteinase-8 (MMP-8) gene expression levels in periodontitis patients accompanied by halitosis. Material and Methods: Samples were obtained from gingival crevicular fluid (GCF) in the deepest pocket and by swabbing in the tongue coating area in patients with periodontitis presenting with halitosis (n = 23) and healthy subjects as controls (n = 7). The values of CH3SH and H2S were obtained using Oral Chroma. The proportion of Pi and MMP-8 expression levels were evaluated using PCR-RT. All the result was statistically analyzed using SPSS software. Results: The levels of CH3SH and H2S in participants with PD ≥ 6 mm showed a robust negative correlation with the proportion of P. intermedia in GCF and tongue coating. No statistically significant association was detected between CH3SH and H2S levels and MMP-8 expression levels (p>0.05). Conclusion: There is no association between CH3SH and H2S levels, the proportion of P. intermedia, and MMP-8 expression in patients with periodontitis accompanied by halitosis.

Original languageEnglish
Article numbere210002
JournalPesquisa Brasileira em Odontopediatria e Clinica Integrada
Publication statusPublished - 24 Jan 2022


  • Halitosis
  • Matrix Metalloproteinase-8
  • Periodontitis
  • Prevotella intermedia


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