TY - JOUR

T1 - Association between the Ratio of Omega-6/Omega-3 Fatty Acids Intake to Plasma Malondialdehyde Level in Patients with Knee Osteoarthritis

AU - Angelia, S. R.

AU - Manikam, N. R.M.

AU - Lubis, A. M.T.

AU - Siagian, C.

AU - Mudjihartini, N.

N1 - Publisher Copyright:
© 2019 Published under licence by IOP Publishing Ltd.

PY - 2019/1/9

Y1 - 2019/1/9

N2 - One of several factors in the pathogenesis of osteoarthritis (OA) is the generation of oxidative stress, inducing lipid peroxidation, and producing malondialdehyde (MDA). Omega-3 fatty acids have role in inhibiting the oxidative stress, but their levels are determined by the omega-6/omega-3 ratio. This study aims to investigate the association between the ratio of omega-6/omega-3 intake and plasma MDA level in knee OA patients. This study was conducted at orthopedic clinic at Bhayangkara Hospital and Cipto Mangunkusumo Hospital, in grade 2-4 of knee OA patients, aged between 40-60 years (n=57). The 1-month-history of omega-3 and omega-6 intake was obtained by using semi-quantitative food frequency questionnaire. The omega-6/omega-3 ratio was calculated by dividing the average daily intake of total omega-6 by the average daily intake of total omega-3. The plasma MDA level was measured by Wills spectrophotometry. The median for omega-3 and omega-6 intake were 0,864 and 6,830 g/day. Thus the ratio of omega-6/omega-3 intake was 8,8:1, and the mean plasma MDA level was 0,773 nmol/mL. Through multiple linear regression test, the results found were the increase of 1 unit of omega-6/omega-3 intake ratio would increase MDA level of 0,023 nmol/mL (β = 0,023, 95% CI = 0,004-0,042, p = 0,017).

AB - One of several factors in the pathogenesis of osteoarthritis (OA) is the generation of oxidative stress, inducing lipid peroxidation, and producing malondialdehyde (MDA). Omega-3 fatty acids have role in inhibiting the oxidative stress, but their levels are determined by the omega-6/omega-3 ratio. This study aims to investigate the association between the ratio of omega-6/omega-3 intake and plasma MDA level in knee OA patients. This study was conducted at orthopedic clinic at Bhayangkara Hospital and Cipto Mangunkusumo Hospital, in grade 2-4 of knee OA patients, aged between 40-60 years (n=57). The 1-month-history of omega-3 and omega-6 intake was obtained by using semi-quantitative food frequency questionnaire. The omega-6/omega-3 ratio was calculated by dividing the average daily intake of total omega-6 by the average daily intake of total omega-3. The plasma MDA level was measured by Wills spectrophotometry. The median for omega-3 and omega-6 intake were 0,864 and 6,830 g/day. Thus the ratio of omega-6/omega-3 intake was 8,8:1, and the mean plasma MDA level was 0,773 nmol/mL. Through multiple linear regression test, the results found were the increase of 1 unit of omega-6/omega-3 intake ratio would increase MDA level of 0,023 nmol/mL (β = 0,023, 95% CI = 0,004-0,042, p = 0,017).

KW - Omega-3 Fatty acids

KW - malondialdehyde

KW - osteoarthritis

UR - http://www.scopus.com/inward/record.url?scp=85060040546&partnerID=8YFLogxK

U2 - 10.1088/1755-1315/217/1/012055

DO - 10.1088/1755-1315/217/1/012055

M3 - Conference article

AN - SCOPUS:85060040546

SN - 1755-1307

VL - 217

JO - IOP Conference Series: Earth and Environmental Science

JF - IOP Conference Series: Earth and Environmental Science

IS - 1

M1 - 012055

T2 - 2nd International Conference on Collaboration Seminar of Chemistry and Industry, CoSCI 2018, in conjunction with 23rd Indonesian Society for Biochemistry and Molecular Biology, ISBMB 2018

Y2 - 11 October 2018 through 12 October 2018

ER -