Association between the Ratio of Omega-6/Omega-3 Fatty Acids Intake to Plasma Malondialdehyde Level in Patients with Knee Osteoarthritis

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Abstract

One of several factors in the pathogenesis of osteoarthritis (OA) is the generation of oxidative stress, inducing lipid peroxidation, and producing malondialdehyde (MDA). Omega-3 fatty acids have role in inhibiting the oxidative stress, but their levels are determined by the omega-6/omega-3 ratio. This study aims to investigate the association between the ratio of omega-6/omega-3 intake and plasma MDA level in knee OA patients. This study was conducted at orthopedic clinic at Bhayangkara Hospital and Cipto Mangunkusumo Hospital, in grade 2-4 of knee OA patients, aged between 40-60 years (n=57). The 1-month-history of omega-3 and omega-6 intake was obtained by using semi-quantitative food frequency questionnaire. The omega-6/omega-3 ratio was calculated by dividing the average daily intake of total omega-6 by the average daily intake of total omega-3. The plasma MDA level was measured by Wills spectrophotometry. The median for omega-3 and omega-6 intake were 0,864 and 6,830 g/day. Thus the ratio of omega-6/omega-3 intake was 8,8:1, and the mean plasma MDA level was 0,773 nmol/mL. Through multiple linear regression test, the results found were the increase of 1 unit of omega-6/omega-3 intake ratio would increase MDA level of 0,023 nmol/mL (β = 0,023, 95% CI = 0,004-0,042, p = 0,017).

Keywords

  • Omega-3 Fatty acids
  • malondialdehyde
  • osteoarthritis

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