TY - JOUR
T1 - Association between serum homocysteine level and cognitive function in middle-aged type 2 diabetes mellitus patients
AU - Damanik, Johanda
AU - Mayza, Andre
AU - Rachman, Andhika
AU - Sauriasari, Rani
AU - Kristanti, Melly
AU - Agustina, Putri Syahida
AU - Angianto, Alexander Randy
AU - Prawiroharjo, Pukovisa
AU - Yunir, Em
N1 - Funding Information:
This work was supported by PITTA Grant 2018 by Directorate of Research and Community Engagement of Universitas Indonesia to EY, Grant numbers award: 2072/UN2.R3.1/HKP.05.00/2018, Funder website: research.ui.ac.id. The funder had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. We would like to express our gratitude to Nida Amalina, an epidemiologist from the Endocrinology and Metabolism Division, Department of Internal Medicine, Universitas Indonesia.
Publisher Copyright:
© 2019 Damanik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Type-2 diabetes mellitus (T2DM) is strongly associated with various complications, including cognitive impairment. Diabetic complication is related with structural and functional changes of brain. Studies investigated that homocysteine as an independent risk factor of several organ complications. This marker might have a role in pathogenesis of cognitive impairment in T2DM patients. We aimed to know the association between serum homocysteine level and cognitive impairment in middle-aged T2DM populations. The study was a cross-sectional study involving 97 T2DM patients aged <60 years old. Cognitive assessment was based on validated Indonesian version of Montreal Cognitive Assessment (MoCA-INA) test. Besides, serum homocysteine level (Hcy) was measured based on standard laboratory assay. Filling out the questionnaire of MoCA-INA was conducted when patients came to take the blood sample. This study used independent t-test, chi-square and multivariate logistic regression model to analyze the data. There were 47 subjects (48.5%) with mild cognitive impairment (MCI). Delayed recall was the most impaired domain (94.8%). There was no significant mean difference of serum Hcy level in MCI and non-MCI group (11.99±3.27 μmol/L vs 12.36±4.07 μmol/L respectively, p = 0.62). Final model of logistic regression showed no association between serum Hcy and cognitive function after adjusting confounding variables (OR: 1.778; 95%CI: 0.69–4.54). Further investigation involving slight elderly T2DM patients with larger sample size should be conducted to confirm this finding.
AB - Type-2 diabetes mellitus (T2DM) is strongly associated with various complications, including cognitive impairment. Diabetic complication is related with structural and functional changes of brain. Studies investigated that homocysteine as an independent risk factor of several organ complications. This marker might have a role in pathogenesis of cognitive impairment in T2DM patients. We aimed to know the association between serum homocysteine level and cognitive impairment in middle-aged T2DM populations. The study was a cross-sectional study involving 97 T2DM patients aged <60 years old. Cognitive assessment was based on validated Indonesian version of Montreal Cognitive Assessment (MoCA-INA) test. Besides, serum homocysteine level (Hcy) was measured based on standard laboratory assay. Filling out the questionnaire of MoCA-INA was conducted when patients came to take the blood sample. This study used independent t-test, chi-square and multivariate logistic regression model to analyze the data. There were 47 subjects (48.5%) with mild cognitive impairment (MCI). Delayed recall was the most impaired domain (94.8%). There was no significant mean difference of serum Hcy level in MCI and non-MCI group (11.99±3.27 μmol/L vs 12.36±4.07 μmol/L respectively, p = 0.62). Final model of logistic regression showed no association between serum Hcy and cognitive function after adjusting confounding variables (OR: 1.778; 95%CI: 0.69–4.54). Further investigation involving slight elderly T2DM patients with larger sample size should be conducted to confirm this finding.
UR - http://www.scopus.com/inward/record.url?scp=85074514567&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0224611
DO - 10.1371/journal.pone.0224611
M3 - Article
C2 - 31693691
AN - SCOPUS:85074514567
SN - 1932-6203
VL - 14
JO - PloS one
JF - PloS one
IS - 11
M1 - e0224611
ER -
