TY - JOUR
T1 - Association between Proinflammatory Cytokines and Anxiety and Depression Symptoms in Rheumatoid Arthritis Patients
T2 - A Cross-sectional Study
AU - Parlindungan, Faisal
AU - Hidayat, Rudy
AU - Ariane, Anna
AU - Shatri, Hamzah
N1 - Funding Information:
This study was funded by Universitas Indonesia, the name of the fund was Universitas Indonesia PITTA B grant scheme, the grant number was: PENG-1/UN2.R3.1/PPM.00/2019).
Publisher Copyright:
© 2023 Parlindungan et al.
PY - 2023
Y1 - 2023
N2 - Background: Rheumatoid arthritis (RA) patients have a greater prevalence of anxiety and depression. Proinflammatory cytokines are elevated in RA. We aim to evaluate the association between systemic inflammation in RA and anxiety and depression. Methods: There were 31 RA patients, 16 with active disease activity and 15 in remission state; they were assessed using the Hospital Anxiety and Depression Scale and for RA disease activity using Disease Activity Score of 28 joints (DAS28) – CRP (C-reactive protein). Serum proinflammatory cytokines were measured, including interleukin (IL)-6, IL-17, and Tumour Necrosis Factor-alpha (TNF-α). Results: Among 31 patients, ten patients showed anxiety symptoms, 19 patients showed depression symptoms, and two displayed mixed symptoms. Serum TNF-α levels were significantly higher in active disease than in the remission group (p-value 0.006). There was no association or correlation between proinflammatory cytokines to anxiety and depression symptoms in the active disease and remission groups. Conclusion: This suggests that other factors besides disease activity and state of systemic inflammation may cause anxiety and depression in RA patients.
AB - Background: Rheumatoid arthritis (RA) patients have a greater prevalence of anxiety and depression. Proinflammatory cytokines are elevated in RA. We aim to evaluate the association between systemic inflammation in RA and anxiety and depression. Methods: There were 31 RA patients, 16 with active disease activity and 15 in remission state; they were assessed using the Hospital Anxiety and Depression Scale and for RA disease activity using Disease Activity Score of 28 joints (DAS28) – CRP (C-reactive protein). Serum proinflammatory cytokines were measured, including interleukin (IL)-6, IL-17, and Tumour Necrosis Factor-alpha (TNF-α). Results: Among 31 patients, ten patients showed anxiety symptoms, 19 patients showed depression symptoms, and two displayed mixed symptoms. Serum TNF-α levels were significantly higher in active disease than in the remission group (p-value 0.006). There was no association or correlation between proinflammatory cytokines to anxiety and depression symptoms in the active disease and remission groups. Conclusion: This suggests that other factors besides disease activity and state of systemic inflammation may cause anxiety and depression in RA patients.
KW - Anxiety
KW - Arthritis rheumatoid
KW - Depression
KW - Inflammation
KW - Interleukin-17
KW - Interleukin-6
KW - Tumor necrosis factor-alpha
UR - http://www.scopus.com/inward/record.url?scp=85163712115&partnerID=8YFLogxK
U2 - 10.2174/17450179-v19-e230510-2022-34
DO - 10.2174/17450179-v19-e230510-2022-34
M3 - Article
AN - SCOPUS:85163712115
SN - 1745-0179
VL - 19
JO - Clinical Practice and Epidemiology in Mental Health
JF - Clinical Practice and Epidemiology in Mental Health
IS - 1
M1 - e174501792304261
ER -
