Association between PM _2.5 and oxidative stress using malondialdehyde biomarker among workers in a concrete batching plant in 2018

Background: Severe air pollution has affected the health of individuals both nationally and globally. The dangerous pollutant PM _2.5 could trigger oxidative damage, which has been widely studied in relation to health problems, such as lung cancer, chronic obstructive pulmonary, and cardiovascular diseases. Malondialdehyde (MDA), which is a secondary product of the lipid peroxidation of polyunsaturated fatty acids, is a marker of oxidative stress.Objective: This study aims to analyze the association between PM _2.5 and MDA concentration in concrete batching plant workers as a population at risk of dust pollution.Material & Method: This research was conducted in April–May 2018 with a cross-sectional method involving 53 samples of workers chosen by simple random sampling. Beside PM _2.5 and MDA concentration, other variables including smoking status, supplement consumption, age, physical activity, body mass index, years of work, and rotational shift working were also studied.Results: The results indicated a significant correlation of PM _2.5 and age with MDA concentrations in concrete batching plant workers. P value between PM _2.5 and MDA concentration was 0.025 with OR 15,791 CI (1,410-176,833). These findings suggest that exposure to PM _2.5 leads to oxidative stress as evidenced by MDA concentration. These findings suggest that exposure to PM _2.5 leads to oxidative stress as evidenced by MDA concentration.