Association between PM 2.5 and oxidative stress using malondialdehyde biomarker among workers in a concrete batching plant in 2018

Research output: Contribution to journalArticle

Abstract

Background: Severe air pollution has affected the health of individuals both nationally and globally. The dangerous pollutant PM 2.5 could trigger oxidative damage, which has been widely studied in relation to health problems, such as lung cancer, chronic obstructive pulmonary, and cardiovascular diseases. Malondialdehyde (MDA), which is a secondary product of the lipid peroxidation of polyunsaturated fatty acids, is a marker of oxidative stress.Objective: This study aims to analyze the association between PM 2.5 and MDA concentration in concrete batching plant workers as a population at risk of dust pollution.Material & Method: This research was conducted in April–May 2018 with a cross-sectional method involving 53 samples of workers chosen by simple random sampling. Beside PM 2.5 and MDA concentration, other variables including smoking status, supplement consumption, age, physical activity, body mass index, years of work, and rotational shift working were also studied.Results: The results indicated a significant correlation of PM 2.5 and age with MDA concentrations in concrete batching plant workers. P value between PM 2.5 and MDA concentration was 0.025 with OR 15,791 CI (1,410-176,833). These findings suggest that exposure to PM 2.5 leads to oxidative stress as evidenced by MDA concentration. These findings suggest that exposure to PM 2.5 leads to oxidative stress as evidenced by MDA concentration.

Original languageEnglish
Pages (from-to)351-356
Number of pages6
JournalIndian Journal of Public Health Research and Development
Volume10
Issue number2
DOIs
Publication statusPublished - 1 Feb 2019

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Keywords

  • Age
  • Concrete batching plant
  • Industry
  • Malondialdehyde (MDA)
  • Oxidative stress
  • PM

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