Association Between Periodontal Disease and Inflammatory Bowel Disease (IBD): A Clinical Evidence-based Review

This article purpose to find out the relationship between periodontitis and IBD further. Literature searches were conducted from articles published in PubMed using keywords “periodontal disease AND periodontitis AND inflammatory bowel disease”, and then the findings were comprehensively summarized and elaborated. The pathogenesis of both diseases, both periodontitis and IBD, are multifactorial, leading to defects in mucosal defenses, deregulation of the immune response, and chronic inflammation of the mucosa. The prevalence of periodontal disease in IBD patients continues to increase. In addition, induction of periodontitis appears to result in dysbiosis in the intestine and alter the function of the intestinal epithelial barrier. There are complex pathogen interactions between periodontal disease and IBD. Therefore, patients with IBD have a higher susceptibility to periodontal disease.