Association between matrix metalloproteinase-1 -1607 1G/2G polymorphism and chronic periodontitis in indonesian population

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Abstract

Objective: This study aimed to identify the distribution of matrix metalloproteinase (MMP)-1 -1607 1G/2G alleles and genotypes in subjects with chronic periodontitis and healthy subjects in a sample of Indonesian population and assess the possible association of this polymorphism with susceptibility to chronic periodontitis. Methods: Genomic DNA samples were obtained from 200 Indonesian males aged 33-78 years old, comprising 100 chronic periodontitis patients and 100 healthy controls. DNA fragments were amplified by a polymerase chain reaction and analyzed by restriction fragment length polymorphism. Results were analyzed by Chi-square test. Results: The frequency of the 2G allele was high both in subjects with periodontitis (87%) and in controls (91%). Analysis of MMP-1 genotype (-1607 1G/2G) showed no significant difference between the chronic periodontitis and healthy groups (p>0.05). Conclusion: The result found no association between MMP-1 -1607 1G/2G polymorphism and susceptibility to chronic periodontitis in Indonesian subjects.

Original languageEnglish
Pages (from-to)15-17
Number of pages3
JournalInternational Journal of Applied Pharmaceutics
Volume12
Issue numberSpecial Issue 1
DOIs
Publication statusPublished - Mar 2020

Keywords

  • Genetic polymorphism
  • Indonesia
  • Matrix metalloproteinases-1
  • Periodontitis

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