Objective: This study aimed to identify the distribution of matrix metalloproteinase (MMP)-1 -1607 1G/2G alleles and genotypes in subjects with chronic periodontitis and healthy subjects in a sample of Indonesian population and assess the possible association of this polymorphism with susceptibility to chronic periodontitis. Methods: Genomic DNA samples were obtained from 200 Indonesian males aged 33-78 years old, comprising 100 chronic periodontitis patients and 100 healthy controls. DNA fragments were amplified by a polymerase chain reaction and analyzed by restriction fragment length polymorphism. Results were analyzed by Chi-square test. Results: The frequency of the 2G allele was high both in subjects with periodontitis (87%) and in controls (91%). Analysis of MMP-1 genotype (-1607 1G/2G) showed no significant difference between the chronic periodontitis and healthy groups (p>0.05). Conclusion: The result found no association between MMP-1 -1607 1G/2G polymorphism and susceptibility to chronic periodontitis in Indonesian subjects.
- Genetic polymorphism
- Matrix metalloproteinases-1