Abstract
Objective: This study aimed to identify the distribution of matrix metalloproteinase (MMP)-1 -1607 1G/2G alleles and genotypes in subjects with chronic periodontitis and healthy subjects in a sample of Indonesian population and assess the possible association of this polymorphism with susceptibility to chronic periodontitis. Methods: Genomic DNA samples were obtained from 200 Indonesian males aged 33-78 years old, comprising 100 chronic periodontitis patients and 100 healthy controls. DNA fragments were amplified by a polymerase chain reaction and analyzed by restriction fragment length polymorphism. Results were analyzed by Chi-square test. Results: The frequency of the 2G allele was high both in subjects with periodontitis (87%) and in controls (91%). Analysis of MMP-1 genotype (-1607 1G/2G) showed no significant difference between the chronic periodontitis and healthy groups (p>0.05). Conclusion: The result found no association between MMP-1 -1607 1G/2G polymorphism and susceptibility to chronic periodontitis in Indonesian subjects.
Original language | English |
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Pages (from-to) | 15-17 |
Number of pages | 3 |
Journal | International Journal of Applied Pharmaceutics |
Volume | 12 |
Issue number | Special Issue 1 |
DOIs | |
Publication status | Published - Mar 2020 |
Keywords
- Genetic polymorphism
- Indonesia
- Matrix metalloproteinases-1
- Periodontitis