TY - JOUR
T1 - Assessment of Coronary Arterial Thrombus by Optical Coherence Tomography
AU - Kume, Teruyoshi
AU - Akasaka, Takashi
AU - Kawamoto, Takahiro
AU - Ogasawara, Yasuo
AU - Watanabe, Nozomi
AU - Toyota, Eiji
AU - Neishi, Yoji
AU - Sukmawan, Renan
AU - Sadahira, Yoshito
AU - Yoshida, Kiyoshi
PY - 2006/6/15
Y1 - 2006/6/15
N2 - We analyzed optical coherence tomographic (OCT) characteristics of different types of coronary thrombi that had been confirmed at postmortem histologic examination. We examined 108 coronary arterial segments of 40 consecutive human cadavers. OCT images of red and white thrombi were obtained and the intensity property of these thrombi was analyzed. Red and white thrombi were found in 16 (17%) and 19 (18%) of the 108 arterial segments, respectively. Red thrombi were identified as high-backscattering protrusions inside the lumen of the artery, with signal-free shadowing in the OCT image. White thrombi were identified as low-backscattering projections in the OCT image. There were no significant differences in peak intensity of OCT signal between red and white thrombi (130 ± 18 vs 145 ± 34, p = 0.12). However, the 1/2 attenuation width of the signal intensity curve, which was defined as the distance from peak intensity to its 1/2 intensity, was significantly different between red and white thrombi (324 ± 50 vs 183 ± 42 μm, p <0.0001). A cut-off value of 250 μm in the 1/2 width of signal intensity attenuation can differentiate white from red thrombi with a sensitivity of 90% and specificity of 88%. We present the first detailed description of the characteristics of different types of coronary thrombi in OCT images. Optical coherence tomography may allow us not only to estimate plaque morphology but also to distinguish red from white thrombi.
AB - We analyzed optical coherence tomographic (OCT) characteristics of different types of coronary thrombi that had been confirmed at postmortem histologic examination. We examined 108 coronary arterial segments of 40 consecutive human cadavers. OCT images of red and white thrombi were obtained and the intensity property of these thrombi was analyzed. Red and white thrombi were found in 16 (17%) and 19 (18%) of the 108 arterial segments, respectively. Red thrombi were identified as high-backscattering protrusions inside the lumen of the artery, with signal-free shadowing in the OCT image. White thrombi were identified as low-backscattering projections in the OCT image. There were no significant differences in peak intensity of OCT signal between red and white thrombi (130 ± 18 vs 145 ± 34, p = 0.12). However, the 1/2 attenuation width of the signal intensity curve, which was defined as the distance from peak intensity to its 1/2 intensity, was significantly different between red and white thrombi (324 ± 50 vs 183 ± 42 μm, p <0.0001). A cut-off value of 250 μm in the 1/2 width of signal intensity attenuation can differentiate white from red thrombi with a sensitivity of 90% and specificity of 88%. We present the first detailed description of the characteristics of different types of coronary thrombi in OCT images. Optical coherence tomography may allow us not only to estimate plaque morphology but also to distinguish red from white thrombi.
UR - http://www.scopus.com/inward/record.url?scp=33744515776&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2006.01.031
DO - 10.1016/j.amjcard.2006.01.031
M3 - Article
C2 - 16765119
AN - SCOPUS:33744515776
SN - 0002-9149
VL - 97
SP - 1713
EP - 1717
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 12
ER -