Asian consensus on the relationship between obesity and gastrointestinal and liver diseases

Jianyi Calvin Koh, Wai Mun Loo, Khean Lee Goh, Kentaro Sugano, Wah Kheong Chan, Wai Yan Philip Chiu, Myung Gyu Choi, Sutep Gonlachanvit, Wei Jei Lee, Wei Jie Jonathan Lee, Yeong Yeh Lee, Laurentius M. Adrianto Lesmana, You Ming Li, Chun Jen Liu, Bunzo Matsuura, Atsushi Nakajima, Enders Kwok Wai Ng, Jose D. Sollano, Simon Kin Hung Wong, Vincent W.S. WongYunsheng Yang, Khek Yu Ho, Yock Young Dan

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41 Citations (Scopus)


The incidence of obesity is increasing in Asia, with implications on gastrointestinal (GI) and liver diseases. The Gut and Obesity in Asia Workgroup comprises regional experts with the aim of studying relationship between obesity and the GI and liver diseases in Asia. Through literature review and the modified Delphi process, consensus statements examining the impact of obesity on esophageal, gastric, pancreatic, colorectal, and liver diseases, exploring relationship between gut microbiome and obesity, and assessing obesity therapies have been produced by the Gut and Obesity in Asia Workgroup. Sixteen experts participated with 9/15 statements having strong consensus (>80% agreement). The prevalence of obesity in Asia is increasing (100% percentage agreement in brackets), and this increased prevalence of obesity will result in a greater burden of obesity-related GI and liver diseases (93.8%). There was consensus that obesity increases the risk of gastric cancer (75%) and colorectal neoplasia (87.5%). Obesity was also associated with Barrett's esophagus and esophageal adenocarcinoma (66.7%) and pancreatic cancer (66.7%) in Asia. The prevalence of non-alcoholic fatty liver disease (NAFLD) in Asia is on the rise (100%), and the risk of NAFLD in Asia (100%) is increased by obesity. Obesity is a risk factor for the development of hepatocellular carcinoma (93.8%). Regarding therapy, it was agreed that bariatric surgery was an effective treatment modality for obesity (93.8%) but there was less agreement on its benefit for NAFLD (62.5%). These experts' consensus on obesity and GI diseases in Asia forms the basis for further research, and its translation into addressing this emerging issue.

Original languageEnglish
Pages (from-to)1405-1413
Number of pages9
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number8
Publication statusPublished - 1 Aug 2016


  • Barrett's esophagus
  • carcinogenesis and metastasis
  • clinical
  • clinical
  • esophageal neoplasms
  • gastric cancer: epidemiology and surveillance
  • hepatocellular carcinoma
  • microbial pathogenesis
  • pancreatic cancer


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