Asia-Pacific Working Group consensus on non-variceal upper gastrointestinal bleeding

Joseph J.Y. Sung, Francis K.L. Chan, Minhu Chen, Jessica Y.L. Ching, K. Y. Ho, Udom Kachintorn, Nayoung Kim, James Y.W. Lau, Jayaram Menon, Abdul Aziz Rani, Nageshwar Reddy, Jose Sollano, Kentaro Sugano, Kelvin K.F. Tsoi, Chun Ying Wu, Neville Yeomans, Namish Vakil, K. L. Goh

Research output: Contribution to journalReview articlepeer-review

151 Citations (Scopus)


Upper gastrointestinal bleeding (UGIB), especially peptic ulcer bleeding, remains one of the most important cause of hospitalisation and mortality world wide. In Asia, with a high prevalence of Helicobacter pylori infection, a potential difference in drug metabolism, and a difference in clinical management of UGIB due to variable socioeconomic environments, it is considered necessary to re-examine the International Consensus of Non-variceal Upper Gastrointestinal Bleeding with emphasis on data generated from the region. The working group, which comprised experts from 12 countries from Asia, recommended the use of the Blatchford score for selection of patients who require endoscopic intervention and which would allow early discharge of patients at low risk. Patients' comorbid conditions should be included in risk assessment. A pre-endoscopy proton pump inhibitor (PPI) is recommended as a stop-gap treatment when endoscopy within 24 h is not available. An adherent clot on a peptic ulcer should be treated with endoscopy combined with a PPI if the clot cannot be removed. Routine repeated endoscopy is not recommended. High-dose intravenous and oral PPIs are recommended but low-dose intravenous PPIs should be avoided. COX-2 selective non-steroidal anti-inflammatory drugs combined with a PPI are recommended for patients with very high risk of UGIB. Aspirin should be resumed soon after stabilisation and clopidogrel alone is no safer than aspirin plus a PPI. When dual antiplatelet agents are used, prophylactic use of a PPI reduces the risk of adverse gastrointestinal events.

Original languageEnglish
Pages (from-to)1170-1177
Number of pages8
Issue number9
Publication statusPublished - Sept 2011


Dive into the research topics of 'Asia-Pacific Working Group consensus on non-variceal upper gastrointestinal bleeding'. Together they form a unique fingerprint.

Cite this