Asbestos-related lung cancer: A hospital-based case-control study in Indonesia

Anna Suraya, Dennis Nowak, Astrid Widajati Sulistomo, Aziza Ghanie Icksan, Elisna Syahruddin, Ursula Berger, Stephan Bose-o’reilly

Research output: Contribution to journalArticle

Abstract

Indonesia has limited data on asbestos-related diseases despite abundant use. This study investigated the risk of occupational asbestos exposure for lung cancer development, utilizing a hospital-based case-control study. Subjects were patients who received a thoracic CT scan at Persahabatan Hospital, Jakarta. The cases had primary lung cancer confirmed by histology, the controls were negative for lung cancer. The cumulative occupational asbestos exposure was calculated by multiplying the exposure intensity by the years of exposure. The exposure intensity was obtained by adopting the weighted arithmetic mean value of asbestos exposure from a job-exposure matrix developed in Korea. The primary data analysis was based on logistic regression. The study included 696 subjects, with 336 cases and 360 controls. The chance of lung cancer for subjects exposed to asbestos was doubled (OR = 2.04, 95% CI = 1.21–3.42) compared with unexposed, and subjects with a cumulative asbestos exposure of 10 fiber-years or more even showed an OR of 3.08 (95% CI = 1.01–9.46). The OR of the combined effect between smoking and asbestos was 8.7 (95% CI = 1.71–44.39); the interaction was consistent with an additive and multiplicative risk model. Asbestos exposure is associated with a higher chance of lung cancer. Improved policies are needed to protect the population from asbestos hazards.

Original languageEnglish
Article number591
JournalInternational Journal of Environmental Research and Public Health
Volume17
Issue number2
DOIs
Publication statusPublished - 2 Jan 2020

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Cancer Care Facilities
Indonesia
Asbestos
Case-Control Studies
Lung Neoplasms
Occupational Exposure
Korea
Histology
Thorax
Logistic Models
Smoking

Keywords

  • Asbestos
  • Indonesia
  • Lung cancer

Cite this

Suraya, Anna ; Nowak, Dennis ; Sulistomo, Astrid Widajati ; Icksan, Aziza Ghanie ; Syahruddin, Elisna ; Berger, Ursula ; Bose-o’reilly, Stephan. / Asbestos-related lung cancer : A hospital-based case-control study in Indonesia. In: International Journal of Environmental Research and Public Health. 2020 ; Vol. 17, No. 2.
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Asbestos-related lung cancer : A hospital-based case-control study in Indonesia. / Suraya, Anna; Nowak, Dennis; Sulistomo, Astrid Widajati; Icksan, Aziza Ghanie; Syahruddin, Elisna; Berger, Ursula; Bose-o’reilly, Stephan.

In: International Journal of Environmental Research and Public Health, Vol. 17, No. 2, 591, 02.01.2020.

Research output: Contribution to journalArticle

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