Application of ultrasound-assisted extraction on the stem bark of rhinachantus nasutus (L.) Kurz, total phenolic, and its potential as antioxidant and inhibitor of alpha-glucosidase enzyme activity

Candra Irawan, Berna Elya, Muhammad Hanafi, Fadlina Chany Saputri

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Aims: This study aims to obtain a stem bark extract of Rhinachantus nasutus (L.) Kurz through the application of ultrasound-assisted extraction (UAE) and reveal: the total phenolic content in the extract; The extract's potential as an antioxidant with copper-reducing strength parameters, and its potential as an antidiabetic by inhibiting alpha-glucosidase activity. Results: The crude ethanol extract of R. nasutus stem bark obtained from the UAE process was 7.4896 g with a yield of 4.99%. The high total phenolic content, namely 677.3343±0.0007 mg GAE / g sample, the antioxidant activity test using the CUPRAC method gave an IC50 value of 18.43±0.20 mg / L. In addition, the ethanol extract of stem bark has a high ability to inhibit the activity of the alpha-glucosidase enzyme with an IC50 value of 10.95±0.28 mg / L. Conclusion: The ethanol extract of the stem bark of R. nasutus from UAE has the potential as a source of antioxidants and antidiabetic.

Original languageEnglish
Pages (from-to)1297-1303
Number of pages7
JournalPharmacognosy Journal
Volume13
Issue number5
DOIs
Publication statusPublished - Sep 2021

Keywords

  • Alpha-glucosidase enzyme
  • Antidiabetic
  • Antioxidant
  • Rhinachantus nasutus (L.) Kurz
  • Total phenolics content
  • Ultrasound-assisted extraction

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