Application of extracellular vesicles derived from mesenchymal stem cells as potential therapeutic tools in autoimmune and rheumatic diseases

Huldani Huldani, Saade Abdalkareem Jasim, Dmitry Olegovich Bokov, Walid Kamal Abdelbasset, Mohammed Nader Shalaby, Lakshmi Thangavelu, Ria Margiana, Maytham T. Qasim

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Mesenchymal stem cells (MSCs) have been proven to have superior potential to be used as therapeutic candidates in various disorders. Nevertheless, the clinical application of these cells have been restricted because of their tumorigenic properties. Increasing evidence has established that the valuable impacts of MSCs are mainly attributable to the paracrine factors including extracellular vesicles (EVs). EVs are nanosized double-layer phospholipid membrane vesicles contain various proteins, lipids and miRNAs which mediate cell‐to‐cell communications. Due to their inferior immunogenicity and tumorigenicity, as well as easier management, EVs have drawn attention as potential cell-free replacement therapy to MSCs. For that reason, herein, we reviewed the recent findings of researches on different MSC-EVs and their effectiveness in the treatment of several autoimmune and rheumatic diseases including multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis, osteoarthritis, osteoporosis, and systemic lupus erythematosus as well as Sjogren's syndrome, systemic sclerosis and other autoimmune diseases.

Original languageEnglish
Article number108634
JournalInternational Immunopharmacology
Volume106
DOIs
Publication statusPublished - May 2022

Keywords

  • Autoimmune diseases
  • Exosomes
  • Mesenchymal stromal cells
  • Microvesicles
  • Rheumatic diseases

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