Antithrombotic effect of Mucuna pruriens L. and Coriandrum sativum

Nuriza Ulul Azmi, Astari Rachma Nityasa, Fadlina Chany Saputri

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Mucuna pruriens (MP) L. and Coriandrum sativum (CS) have been found for in vitro antithrombotic activity. However, the in vivo studies for both plants have not been discovered yet. Objective: The objective of the study is to prove the efficacy of MP L. and CS by conducting in vivo antithrombotic activity test with bleeding time and survival rate as the parameters. Materials and Methods: MP and CS extracts with three different doses were given orally to the experimental animals for 7 days. Aspirin was used as a positive control. The bleeding time was observed on mice tail that had been cut, and the survival rate was determined by inducing thrombosis with collagen-epinephrine injection. Results: Seven-day treatment of plant extracts significantly prolonged the bleeding time of the treated group compared to the normal control group. The result demonstrated the increasing number of survived animals in the treated group compared to the negative control group. Conclusion: Both extracts had shown antithrombotic activity by significantly prolonged the bleeding time and increased the survival rate.

Original languageEnglish
Pages (from-to)413-417
Number of pages5
JournalPharmacognosy Journal
Volume11
Issue number2
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • Antithrombotic
  • Bleeding time
  • Collagen
  • Coriandrum sativum
  • Mucuna pruriens L
  • Survival rate

Fingerprint Dive into the research topics of 'Antithrombotic effect of Mucuna pruriens L. and Coriandrum sativum'. Together they form a unique fingerprint.

  • Cite this