Antithrombotic effect of Kaempferia galanga L. and Curcuma xanthorrhiza Roxb. On collagen-epinephrine induced thromboembolism in mice

Fadlina Chany Saputri, Chavella Avatara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Kaempferia galanga L. and Curcuma xanthorrhiza Roxb. have been proven to possess antiplatelet activity in vitro. The aim of this study is to investigate the antithrombotic effect of the rhizome extracts of Kaempferia galanga L. and Curcuma xanthorrhiza Roxb in a mouse thrombotic model. Methods: The ethanol extracts of K. galanga and C. xanthorrhiza were orally administered with three different doses (7, 14 and 28 mg/20 g BW) in two experimental mouse models. Bleeding time prolongation was observed on mice tail that had been cut and the survival rate of mice was observed after thromboembolism induction by collagen-epinephrine. These two experiments were observed after 7 days extracts pre-treatment and compared to the positive control, aspirin. Results: A potent effect of K. galanga and C. xanthorrhiza extracts were demonstrated through significant bleeding time prolongation compared to control group. C. xanthorrhiza extract exhibited better activity than K. galanga extract. Moreover, both K. galanga and C. xanthorrhiza extracts significantly protected mice from thromboembolic death, where the protective effect of C. xanthorrhiza extract was stronger than K. galanga extract in a dose-dependent manner. Conclusion: K. galanga and C. xanthorrhiza extracts have a potential to be developed as antithrombotic agents against platelet thromboembolism.

Original languageEnglish
Pages (from-to)1149-1153
Number of pages5
JournalPharmacognosy Journal
Volume10
Issue number6
DOIs
Publication statusPublished - 1 Nov 2018

Keywords

  • Antithrombotic
  • Bleeding time
  • Curcuma xanthorrhiza Roxb
  • Kaemp eria galanga L
  • Survival rate

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