Antithrombotic activity of Tamarindus Indica L. In mice

Objective: This study aimed to investigate the antithrombotic activity of Tamarindus indica L. extract (TIE) in mouse models (in vivo). Methods: TIE was orally administered to mice at three different doses for 7 days. TIE-treated mice were used in two experiments of antithrombotic activity: An examination of bleeding time following tail cutting and an examination of survival rate after collagen-epinephrine-induced thromboembolism. The TIE groups were observed after 7 days of treatment and compared to an aspirin-treated group and a control group. Results: Treatment with TIE led to a significant increase in bleeding time compared with that in the control group. TIE treatment also protected mice from thromboembolic death, significantly increasing survival rates in a dose-dependent manner. Conclusion: TIE has the potential as an antithrombotic agent against platelet thromboembolism.