Antithrombotic activity of Tamarindus Indica L. In mice

Fadlina Chany Saputri; Chavella Avatara; Dian Rachmawati

doi:10.22159/ijap.2018.v10s1.08

Antithrombotic activity of Tamarindus Indica L. In mice

Fadlina Chany Saputri, Chavella Avatara, Dian Rachmawati

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Objective: This study aimed to investigate the antithrombotic activity of Tamarindus indica L. extract (TIE) in mouse models (in vivo). Methods: TIE was orally administered to mice at three different doses for 7 days. TIE-treated mice were used in two experiments of antithrombotic activity: An examination of bleeding time following tail cutting and an examination of survival rate after collagen-epinephrine-induced thromboembolism. The TIE groups were observed after 7 days of treatment and compared to an aspirin-treated group and a control group. Results: Treatment with TIE led to a significant increase in bleeding time compared with that in the control group. TIE treatment also protected mice from thromboembolic death, significantly increasing survival rates in a dose-dependent manner. Conclusion: TIE has the potential as an antithrombotic agent against platelet thromboembolism.

Original language	English
Pages (from-to)	35-38
Number of pages	4
Journal	International Journal of Applied Pharmaceutics
Volume	10
Issue number	Special Issue 1
DOIs	https://doi.org/10.22159/ijap.2018.v10s1.08
Publication status	Published - 1 Dec 2018

Keywords

Antithrombotic
Bleeding time
Survival rate
Tamarindus indica L

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10.22159/ijap.2018.v10s1.08

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title = "Antithrombotic activity of Tamarindus Indica L. In mice",

abstract = "Objective: This study aimed to investigate the antithrombotic activity of Tamarindus indica L. extract (TIE) in mouse models (in vivo). Methods: TIE was orally administered to mice at three different doses for 7 days. TIE-treated mice were used in two experiments of antithrombotic activity: An examination of bleeding time following tail cutting and an examination of survival rate after collagen-epinephrine-induced thromboembolism. The TIE groups were observed after 7 days of treatment and compared to an aspirin-treated group and a control group. Results: Treatment with TIE led to a significant increase in bleeding time compared with that in the control group. TIE treatment also protected mice from thromboembolic death, significantly increasing survival rates in a dose-dependent manner. Conclusion: TIE has the potential as an antithrombotic agent against platelet thromboembolism.",

keywords = "Antithrombotic, Bleeding time, Survival rate, Tamarindus indica L",

author = "Saputri, {Fadlina Chany} and Chavella Avatara and Dian Rachmawati",

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AU - Saputri, Fadlina Chany

AU - Avatara, Chavella

AU - Rachmawati, Dian

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Objective: This study aimed to investigate the antithrombotic activity of Tamarindus indica L. extract (TIE) in mouse models (in vivo). Methods: TIE was orally administered to mice at three different doses for 7 days. TIE-treated mice were used in two experiments of antithrombotic activity: An examination of bleeding time following tail cutting and an examination of survival rate after collagen-epinephrine-induced thromboembolism. The TIE groups were observed after 7 days of treatment and compared to an aspirin-treated group and a control group. Results: Treatment with TIE led to a significant increase in bleeding time compared with that in the control group. TIE treatment also protected mice from thromboembolic death, significantly increasing survival rates in a dose-dependent manner. Conclusion: TIE has the potential as an antithrombotic agent against platelet thromboembolism.

AB - Objective: This study aimed to investigate the antithrombotic activity of Tamarindus indica L. extract (TIE) in mouse models (in vivo). Methods: TIE was orally administered to mice at three different doses for 7 days. TIE-treated mice were used in two experiments of antithrombotic activity: An examination of bleeding time following tail cutting and an examination of survival rate after collagen-epinephrine-induced thromboembolism. The TIE groups were observed after 7 days of treatment and compared to an aspirin-treated group and a control group. Results: Treatment with TIE led to a significant increase in bleeding time compared with that in the control group. TIE treatment also protected mice from thromboembolic death, significantly increasing survival rates in a dose-dependent manner. Conclusion: TIE has the potential as an antithrombotic agent against platelet thromboembolism.

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KW - Bleeding time

KW - Survival rate

KW - Tamarindus indica L

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JO - International Journal of Applied Pharmaceutics

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Antithrombotic activity of Tamarindus Indica L. In mice

Abstract

Keywords

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