Antithrombotic activity of Tamarindus Indica L. In mice

Fadlina Chany Saputri, Chavella Avatara, Dian Rachmawati

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: This study aimed to investigate the antithrombotic activity of Tamarindus indica L. extract (TIE) in mouse models (in vivo). Methods: TIE was orally administered to mice at three different doses for 7 days. TIE-treated mice were used in two experiments of antithrombotic activity: An examination of bleeding time following tail cutting and an examination of survival rate after collagen-epinephrine-induced thromboembolism. The TIE groups were observed after 7 days of treatment and compared to an aspirin-treated group and a control group. Results: Treatment with TIE led to a significant increase in bleeding time compared with that in the control group. TIE treatment also protected mice from thromboembolic death, significantly increasing survival rates in a dose-dependent manner. Conclusion: TIE has the potential as an antithrombotic agent against platelet thromboembolism.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalInternational Journal of Applied Pharmaceutics
Volume10
Issue numberSpecial Issue 1
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • Antithrombotic
  • Bleeding time
  • Survival rate
  • Tamarindus indica L

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