Antioxidative and cytotoxic effects of prenylated stilbene derivative-rich Melinjo (Gnetum gnemon L.) fruit rind

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5 Citations (Scopus)

Abstract

The identification of fruit-bark of Melinjo was carried out using fractionation column chromatography resulted in 3 isolates A-C with presumption of containing five stilbene derivatives compounds (isorhapontigenin, resveratrol, gnetin D, gnetifolin K, gnetol) and one lignan compound ((+)-lirioresinol B) based on the results of the characterization of UV-Vis, FTIR, and LC-ESI-MS. Isolate C that containing gnetol and (+)-lirioresinol B was reacted through prenylation process with prenyl bromide as a source of prenyl group and K2CO3 as catalyst with reflux system at 60 °C for 24 h. Characterization using LC-ESI-MS showed that gnetol and (+)-lirioresinol B was successfully prenylated with one additional prenyl group. The prenylated stilbene showed comparable antioxidant effect and was slightly lower than the nature stilbene structure, as the impact of the attachment of prenyl moieties at their hydroxyl groups in stilbene, and showed moderate activity against P-388 murine leukemia b cells. The observed inhibition of the bioactivity test provides a reasonable mechanism for the potent cancer chemo preventive activity of prenylated stilbene compounds and may pose this compound as a valuable agent for the treatment of diseases.

Original languageEnglish
Title of host publicationInternational Symposium on Current Progress in Mathematics and Sciences 2015, ISCPMS 2015
Subtitle of host publicationProceedings of the 1st International Symposium on Current Progress in Mathematics and Sciences
EditorsTerry Mart, Djoko Triyono
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735413764
DOIs
Publication statusPublished - 19 Apr 2016
Event1st International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2015 - Depok, Indonesia
Duration: 3 Nov 20154 Nov 2015

Publication series

NameAIP Conference Proceedings
Volume1729
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference1st International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2015
CountryIndonesia
CityDepok
Period3/11/154/11/15

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