Antioxidant effects of methanolic extract of phaleria macrocarpa (Scheff.) boerl in fructose 10%-induced rats

The present study was carried out to investigate whether methanolic extract of Phalleria macrocarpa (Scheff) Boerl fruits (PM) mitigates oxidative stress in fructose fed rats. Male Sprague Dawley rats were fed with fructose 10% w/v ad libitum for 8 weeks. The rats (n = 36) were divided into six groups (of six each); normal control, negative control, captopril 10 mg/kg BW and extract methanolic P. Marcocarpha (PM)at the dose0.5, 1, 2 g/kg BW, were given start at week 6 until week 8 and 1 g/kg BW were given for 8 weeks. After completion of treatment schedule rats from each group were anesthetized with urethane (120 mg/100 gm, intraperitoneal). Blood was collected and then centrifugated to obtain plasma and later store at-70°C. Plasma glucose, lipid peroxidation markers and antioxidant enzyme (MDA, GSH, and SOD) were analyzed in all the groups. Fructose consumption increased SOD and glucose plasma level and reduced GSH and SOD activity, whereas these levels were near-normal in the rats consuming PM and captopril.