Antioxidant compound from Myristica fatua Houtt Leaves

S. Fajriah, M. Megawati, A. Darmawan, S. Hudiyono, S. Kosela, M. Hanafi

Research output: Contribution to journalConference articlepeer-review


Antioxidant plays an important role in reducing the risk of chronic diseases. By using DPPH radical scavenging assay-guided fractionation, a bioactive compound has been isolated from the methanol extract of the leaves of Myristica fatua Houtt and subsequently identified as methyl 3,4-dihydroxybenzoic (MDB). The structure of MDB was confirmed by UV, FT-IR, MS, 1- and 2-D NMR spectroscopy. This compound exhibit antioxidant activity together with previous compounds i.e (7S,8R,8'S,7'S)-7,7'-bis(3-hydroxy-5-methoxyphenyl)-8,8'-dimethylbuthane-7,7'-diol and 3"-hydroxy demethyldactyloidin with IC values 7.96, 101.1 and 15.4 µg/mL, respectively. These findings demonstrate that MDB can be considered as a natural antioxidant.

Original languageEnglish
Article number012035
JournalIOP Conference Series: Materials Science and Engineering
Issue number1
Publication statusPublished - 4 Jan 2021
Event6th International Symposium on Applied Chemistry, ISAC 2020 - Tangerang, Indonesia
Duration: 18 Nov 202020 Nov 2020


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