Mistletoe, Dendrophthoe pentandra (L.) Miq., was reported to be the most frequently obligate hemiparasite species found in Kampus UI, Depok. Mistletoe has been reported containing bioactive compound metabolites. This research investigated the antioxidant activity of three mistletoe individuals live on different host plants in Kampus UI. The host plants are Mangifera indica, Bauhinia pupurea and Stelechocarpus burahol. Samples extracted with methanol to yield crude extracts and DPPH (1,1-Diphenyl-2-Picrylhydrazyl) method was used to test the antioxidant activity. The results showed that all extract of mistletoe has antioxidant activities with a range IC50 value of 10-25 μg/mL. The HPLC analysis showed that each extract has quite similar chromatogram profile. Meanwhile, the total flavonoid and phenolic compound from all the extract range are 37.64-52.92 g QE/100 g and 349.6-431.6 mg GAE/100 g. These results suggested that mistletoe extracts might have interesting bioactive metabolites as an antioxidant and therefore should be further investigated for isolation and structure elucidation. This research also gives a conclusion that different host plants seem to have almost the same metabolites composition.