Antimicrobial Compound from Endophytic Pseudomonas azotoformans UICC B-91 of Neesia altissima (Malvaceae)

Rina Hidayati Pratiwi, Eva Oktarina, Wibowo Mangunwardoyo, Iman Hidayat, Endang Saepudin

Research output: Contribution to journalArticlepeer-review

Abstract

Centrifugated extract of endophytic Pseudomonas azotoformans strain UICC B-91 has been observed for its antimicrobial activity against Escherichia coli ATCC 8739, Bacillus cereus ATCC 10876, Staphylococcus aureus ATCC 6583, Staphylococcus aureus ATCC 25923, Salmonella typhimurium ATCC 25241, Pseudomonas aeruginosa ATCC 15442, Bacillus subtilis ATCC 19659 and Candida albicans ATCC 10231, with minimum concentration in the range 250 µg/mL. But, the novel compound of the bioactive substances which relevant for antimicrobial activity have not been described. Further fractionation and identification of the extract by thin layer chromatography (TLC) and liquid chromatography mass spectrophotometry (LCMS-MS) detected several compound as futoamide (C18H23NO3), gentialutine (C9H11NO), gentiabetine (C9H11NO2), 1-[(2E,4E)-2,4-decadienoyl]pyrrolidine (C14H23NO), lycopodine (C16H25NO) and dihydrolycopodine (C16H27NO). The majority compounds containing CHON elements with molecular weight approximately 100-450 Da.

Original languageEnglish
Pages (from-to)172-181
Number of pages10
JournalPharmacognosy Journal
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2022

Keywords

  • Alkaloid
  • Antimicrobial compound
  • Extraction
  • P. azotoformans

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