Antihypercholesterolemia effect of acalypha indica l. To serum lipid profile and histopathology liver on sprague dawley rats: Focused on gemfibrozil as a control

Hypercholesterolemia is a common metabolic disorder found worldwide, which is associated with dyslipidemia and cardiovascular disease incidence. Among the first line choices drugs is gemfibrozil but it has side effect gastrointestinal disorder. The aim of this study is to investigate anti hypercholesterolemia effect of ethanol extract of Acalypha indica roots (AI Extract) on plasma lipid profile and fatty liver tissue, compared to gemfibrozil. Male Sprague-Dawley rats were assigned to five groups (n = 6) and give the intervention for 4 weeks. One normal group receive normal feed, one group still induce with high fructose-cholesterol diet (HFCD), while the others were supplemented with 250 mg/kgBW AI extract, 10 mg/kgBW gemfibrozil and combination between 250 mg/kgBW AI extract+10 mg/kgBB gemfibrozil. Total cholesterol were analyzed with Kruskal Wallis test and post hoc Mann-Whitney test. Meanwhile, HDL, LDL, triglycerides and atherogenic index were analyzed with One Way ANOVA test and post hoc Mann-Whitney test. There are statistically significant difference results in all lipid plasma profile: Total Cholesterol, (p < 0, 0001), triglyseride (p = 0, 0002) HDL (p = 0,0276), LDL (P <0, 0001) and Atherohenic index (p<0, 0001) in administration of Ai extract+gemfibrozil group compared to control groups. Hypercholesterolemia.liver tissues were assessed using Clinical Research Network Scoring for Non Alcoholic Steatohepatitis (NASH). Gemfibrozil and AI gemfibrozil are significantly reduced lipid deposition in fatty liver tissue (p <0.05), compare with control group. In conclusion, the result of this study indicated that the extract of AI extract can be used as alternative therapy for anti hypercholesterolemia.