Antifungal effect of Cuminum cyminum extract on candida albicans ATCC 10231 (experimental laboratory)

Anis Dien Hartini, Primodanti Jiwanakusuma, Anggraini Margono, Endang Suprastiwi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Candida albicans causes persistent endodontic infections; however, current antifungal materials for C. albicans infection have some limitations. Because Cuminum cyminum (cumin) has antifungal properties, its efficacy against C. albicans ATCC 10231 was investigated using Sabouraud Dextrose Broth (SDB). Steam distillation technique was used to obtain 5 different concentrations of cumin extract (0.1, 0.2, 0.4, 0.8, and 1.6 μL/mL). To evaluate the antifungal effect of cumin extract, the turbidity of C. albicans was assessed with an enzyme-linked immunosorbent assay (ELISA) reader. The cumin extract concentration that resulted in the lowest turbidity value of C. albicans ATCC 10231 was 0.4 μL/mL, which was significantly different from those produced by concentrations 0.1, 0.2 μL/mL, and the control. The concentration that resulted in the lowest turbidity of the biofilm was 0.1 μL/mL; however, this finding was not significantly different from biofilm turbidity values of other groups. Turbidity was lower for the planktonic form than for the biofilm which was significantly different from those produced by concentrations 0.4, 0.8, and 1.6 μL/mL. In conclusion cumin extract has an antifungal effect on both planktonic and biofilm forms of C. albicans ATCC 10231. Furthermore, it is more effective against planktonic than biofilm form.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalJournal of International Dental and Medical Research
Volume12
Issue number1
Publication statusPublished - 1 Jan 2019

Keywords

  • Candida albicans
  • Cumin extract
  • Cuminum cyminum

Fingerprint Dive into the research topics of 'Antifungal effect of Cuminum cyminum extract on candida albicans ATCC 10231 (experimental laboratory)'. Together they form a unique fingerprint.

  • Cite this