Antibodi Campak pada Bayi Baru Lahir dan Faktor yang Memengaruhi

Background. Maternal measles antibodies from their mother which is transferred during pregnancy will protect the newborn from measles. However, these maternal antibodies will gradually decline after birth. The duration of protection by the antibodies in the newborn has positive correlation with the level of maternal antibodies, but some factors can influence its duration as well. Objectives. To measure the measles antibody titer in the newborn and to correlate it with the factors that influenced its existence. Methods. A cross sectional study was conducted at RSUD Dr. Zainoel Abidin Hospital at Banda Aceh, from March to April 2015. Newborns who met the inclusion and exclusion criteria were selected through consecutive nonprobability sampling. Parents were interviewed and the New Ballard Score was used to measure the prematurity. Blood samples for Measles antibodies were taken from umbilical cord and the level was examined at Prodia Laboratory in Jakarta. The T-test analysis performed to determine the mean titer by sex, birth weight for gestational age, gestational age, maternal age, parity, and co-morbidity of the mother. Logistic regression analysis was used to find the factors that influenced measles antibodies titer. Sixty eight newborns were enrolled into the study. Results. Sixty-four out of 68 newborns had positive measles antibodies with the mean titer was (2277.7 ± 1830.7) IU/l. We found preterm babies (jumlahnya berapa? (2061.94 ± 1554.44 IU/l) have lower titer than term baby (3006.83 ± 1613.79) IU/l, although the difference was not statistically significant. These findings are consistent with other factors as well as, male sex, preterm, birth weight inappropriate for gestational age, mother with comorbidity had lower titer, however statistically was not significant. Conclusions. Majority of newborns had positive maternal measles antibodies with the mean total titer were (2277,7 ± 1830,7) IU/l. We did not find any significant variables that influenced maternal measles antibodies titer in the newborns.