Antibacterial effectiveness of 2% chitosan and 2% chlorhexidine against enterococcus faecalis in biofilm (Laboratory experiment)

Priscilla Arlyta Simanjuntak, Nilakesuma Djauharie, Bambang Nursasongko

Research output: Contribution to journalArticle

Abstract

Objective: Enterococcus faecalis can form biofilms and has a major role in the etiology of persistent lesions after root canal. We analyzed the efficacy of chitosan and chlorhexidine against E. faecalis in biofilms. Methods: Polymerase chain reaction was used to analyze E. faecalis DNA that survived and lived after immersing the biofilm in an antibacterial solution. Results: A statistically significant difference was noted in living E. faecalis between chitosan and control and between 2% chlorhexidine and control groups (p≤0.05). No significant difference was noted between chitosan and chlorhexidine groups (p>0.05). Conclusions: Antibacterial effectivity of chitosan is equal to that of chlorhexidine against E. faecalis in biofilm.

Original languageEnglish
Pages (from-to)44-48
Number of pages5
JournalInternational Journal of Applied Pharmaceutics
Volume11
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • Chitosan
  • Chlorhexidine
  • Enterococcus faecalis
  • Real-time polymerase chain reaction

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