This study tried to modify the surface of silicone, which is widely used as a mobile phone case, so it has antibacterial and self-cleaning ability. The silicone surface was coated using Ag-TiO2 (silver-titania), prepared by the photo-assisted deposition (PAD) method. Before the coating process, the hydrophobic silicone surface was treated with UV-C radiation. This study aimed to obtain the optimal Ag (silver) loading on antibacterial and self-sterilization performance and the effect of UV-C irradiation and addition of TEOS (Tetraethyl orthosilicate) to the resulted coating. To see the difference of Ag addition, sampleswere characterized using UV-Vis DRS. The results showed that UV-C irradiation and the addition of TEOS additives wereeffective in producing a strong coating. Under the UV irradiation, the degradation rate of methylene blue dye used to represent the self-cleaning ability. Silicone which was loaded with 0.5% Ag showed 78.09% of degradation within 2 hourswhile the TiO2 only shows 20.09% of degradation. Meanwhile, the addition of larger loading of Ag (1%, 1.5%, 3% and 6%)will reduce the degradation ability. As for the disinfection performance, 1.5% Ag showed the best results among others. Iteffectively decreased the E.coli colonies growth by 20.91%, while the blank and TiO2 (titania) coated silicone respectively showed 10.23% and 0% growth of E.coli colonies within 10 minutes in dark conditions. The addition of larger loading of Ag also showed the same effect as on the self-cleaning test. This kind of silicone is very promising, especially in this pandemic era.