TY - JOUR
T1 - Anti-Müllerian hormone as a predictor of polycystic ovary syndrome treated with clomiphene citrate
AU - Hestiantoro, Andon
AU - Negoro, Yuwono Sri
AU - Afrita, Yohana
AU - Wiweko, Budi
AU - Sumapradja, Kanadi
AU - Natadisastra, Muharam
N1 - Publisher Copyright:
© 2016. THE KOREAN SOCIETY FOR REPRODUCTIVE MEDICINE.
PY - 2016
Y1 - 2016
N2 - Objective: This study aimed to determine the threshold of anti-Müllerian hormone (AMH) as predictor of follicular growth failure in polycystic ovary syndrome (PCOS) patients treated with clomiphene citrate (CC). Methods: Fifty female subjects with PCOS were recruited and divided into two groups based on successful and unsuccessful follicular growth. Related variables such as age, infertility duration, cigarette smoking, use of Moslem hijab, sunlight exposure, fiber intake, body mass index, waist circumference, AMH level, 25-hydroxy vitamin D level, and growth of dominant follicles were obtained, assessed, and statistically analyzed. Results: The AMH levels of patients with successful follicular growth were significantly lower (p=0.001) than those with unsuccessful follicular growth (6.10±3.52 vs. 10.43±4.78 ng/mL). A higher volume of fiber intake was also observed in the successful follicular growth group compared to unsuccessful follicular growth group (p=0.001). Our study found the probability of successful follicle growth was a function of AMH level and the amount of fiber intake, expressed as Y=-2.35+(-0.312×AMH level)+(0.464×fiber intake) (area under the curve, 0.88; 95% confidence interval, 0.79-0.98; p<0.001). Conclusion: The optimal threshold of AMH level in predicting the failure of follicle growth in patients with PCOS treated with CC was 8.58 ng/mL.
AB - Objective: This study aimed to determine the threshold of anti-Müllerian hormone (AMH) as predictor of follicular growth failure in polycystic ovary syndrome (PCOS) patients treated with clomiphene citrate (CC). Methods: Fifty female subjects with PCOS were recruited and divided into two groups based on successful and unsuccessful follicular growth. Related variables such as age, infertility duration, cigarette smoking, use of Moslem hijab, sunlight exposure, fiber intake, body mass index, waist circumference, AMH level, 25-hydroxy vitamin D level, and growth of dominant follicles were obtained, assessed, and statistically analyzed. Results: The AMH levels of patients with successful follicular growth were significantly lower (p=0.001) than those with unsuccessful follicular growth (6.10±3.52 vs. 10.43±4.78 ng/mL). A higher volume of fiber intake was also observed in the successful follicular growth group compared to unsuccessful follicular growth group (p=0.001). Our study found the probability of successful follicle growth was a function of AMH level and the amount of fiber intake, expressed as Y=-2.35+(-0.312×AMH level)+(0.464×fiber intake) (area under the curve, 0.88; 95% confidence interval, 0.79-0.98; p<0.001). Conclusion: The optimal threshold of AMH level in predicting the failure of follicle growth in patients with PCOS treated with CC was 8.58 ng/mL.
KW - Anti-Müllerian hormone
KW - Clomiphene citrate
KW - Ovarian follicle
KW - Polycystic ovary syndrome
UR - http://www.scopus.com/inward/record.url?scp=85010520698&partnerID=8YFLogxK
U2 - 10.5653/cerm.2016.43.4.207
DO - 10.5653/cerm.2016.43.4.207
M3 - Article
AN - SCOPUS:85010520698
VL - 43
SP - 207
EP - 214
JO - Clinical and Experimental Reproductive Medicine
JF - Clinical and Experimental Reproductive Medicine
SN - 2233-8233
IS - 4
ER -