TY - JOUR
T1 - Anti-inflammatory Effects of Hibiscus Sabdariffa Linn. on the IL-1β/IL-1ra Ratio in Plasma and Hippocampus of Overtrained Rats and Correlation with Spatial Memory
AU - Bayani, Gulshan Fahmi El
AU - Marpaung, Nurasi Lidya E.
AU - Simorangkir, Dedy Arnold Sastrajaya
AU - Sianipar, Imelda Rosalyn
AU - Ibrahim, Nurhadi
AU - Kartinah, Neng Tine
AU - Mansur, Indra Gusti
AU - Purba, Jan S.
AU - Ilyas, Ermita I.Ibrahim
PY - 2018/10/15
Y1 - 2018/10/15
N2 - Overtraining leads to an increase in IL-1β systemically due to muscle microtrauma, which affects the hippocampus, an important structure in spatial memory consolidation. The administration of Hibiscus sabdariffa Linn is expected to decrease IL-1β and increase IL-1ra, thereby potentially preventing impairments in spatial memory consolidation. This research was an experimental study using 20 male Wistar rats. The overtraining of Wistar rats altered the ratio of IL-1β/IL-1ra in the plasma and hippocampus. Moreover, this overtraining impaired spatial memory consolidation. The methanol extract of H. sabdariffa improved spatial memory consolidation in Wistar rats and prevented impairment in spatial memory consolidation by maintaining the ratio of IL-1β/IL-1ra in the plasma and hippocampus of Wistar rats who experienced overtraining. H. sabdariffa is a potent anti-inflammatory substance that prevents impairments in spatial memory consolidation in overtrained Wistar rats.
AB - Overtraining leads to an increase in IL-1β systemically due to muscle microtrauma, which affects the hippocampus, an important structure in spatial memory consolidation. The administration of Hibiscus sabdariffa Linn is expected to decrease IL-1β and increase IL-1ra, thereby potentially preventing impairments in spatial memory consolidation. This research was an experimental study using 20 male Wistar rats. The overtraining of Wistar rats altered the ratio of IL-1β/IL-1ra in the plasma and hippocampus. Moreover, this overtraining impaired spatial memory consolidation. The methanol extract of H. sabdariffa improved spatial memory consolidation in Wistar rats and prevented impairment in spatial memory consolidation by maintaining the ratio of IL-1β/IL-1ra in the plasma and hippocampus of Wistar rats who experienced overtraining. H. sabdariffa is a potent anti-inflammatory substance that prevents impairments in spatial memory consolidation in overtrained Wistar rats.
KW - Hibiscus sabdariffa Linn.
KW - IL-1ra
KW - IL-1β
KW - Plasma
KW - hippocampus
KW - overtraining
KW - spatial memory consolidation
UR - http://www.scopus.com/inward/record.url?scp=85055843515&partnerID=8YFLogxK
M3 - Article
C2 - 30381729
AN - SCOPUS:85055843515
SN - 0023-2513
VL - 64
SP - E73-E83
JO - The Kobe journal of medical sciences
JF - The Kobe journal of medical sciences
IS - 2
ER -