Anti-inflammatory Effects of Hibiscus Sabdariffa Linn. on the IL-1β/IL-1ra Ratio in Plasma and Hippocampus of Overtrained Rats and Correlation with Spatial Memory

Gulshan Fahmi El Bayani, Nurasi Lidya E. Marpaung, Dedy Arnold Sastrajaya Simorangkir, Imelda Rosalyn Sianipar, Nurhadi Ibrahim, Neng Tine Kartinah, Indra Gusti Mansur, Jan S. Purba, Ermita I.Ibrahim Ilyas

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Overtraining leads to an increase in IL-1β systemically due to muscle microtrauma, which affects the hippocampus, an important structure in spatial memory consolidation. The administration of Hibiscus sabdariffa Linn is expected to decrease IL-1β and increase IL-1ra, thereby potentially preventing impairments in spatial memory consolidation. This research was an experimental study using 20 male Wistar rats. The overtraining of Wistar rats altered the ratio of IL-1β/IL-1ra in the plasma and hippocampus. Moreover, this overtraining impaired spatial memory consolidation. The methanol extract of H. sabdariffa improved spatial memory consolidation in Wistar rats and prevented impairment in spatial memory consolidation by maintaining the ratio of IL-1β/IL-1ra in the plasma and hippocampus of Wistar rats who experienced overtraining. H. sabdariffa is a potent anti-inflammatory substance that prevents impairments in spatial memory consolidation in overtrained Wistar rats.

Original languageEnglish
Pages (from-to)E73-E83
JournalThe Kobe journal of medical sciences
Volume64
Issue number2
Publication statusPublished - 15 Oct 2018

Keywords

  • Hibiscus sabdariffa Linn.
  • IL-1ra
  • IL-1β
  • Plasma
  • hippocampus
  • overtraining
  • spatial memory consolidation

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