Anti-Elastase, Antioxidant, Total Phenolic and Total Flavonoid Content of Wuru Ketek (Myrica javanica Reinw. Ex BL.) from Tangkuban Perahu, West Java - Indonesia

Varda Arianti, Berna Elya, Iskandarsyah

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: The presence of elastase and ROS can cause skin aging, phenolic compounds and flavonoids can be used to inhibit elastase activity and as an antioxidant. Objective: This research aimed to evaluate the anti-elastase, antioxidant activities, TPC and TFC of extracts from Myrica javanica. Methods: In this study, the leaves, stems and fruit of Myrica javanica were macerated with 96% ethanol. The extracts obtained were analysed for anti-elastase and antioxidant activities. It was also evaluated for TPC and TFC. Result: IC50 anti-elastase on leaves extract (LE), stems extract (SE), and fruits extract (FE) respectively showed 64.71 ppm, 197.49 ppm, and no activity. The anti-elastase result of three extracts are lower if compared with Myricetine (9.54 ppm). SE showed highest DPPH and TPC value (IC50=16.36 µg/mL; 307.00 mgGAE/g dry weight) and LE showed highest FRAP and TFC value (421.68 Mol/gram; 15.80 mgQE/g dry weight). Conclusion: In summary, anti-elastase and antioxidant activity are influenced by differences in the content of compounds in the extract.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalPharmacognosy Journal
Volume12
Issue number2
DOIs
Publication statusPublished - 2020

Keywords

  • Anti-elastase
  • Antiaging
  • Antioxidant
  • Myrica javanica
  • TFC
  • TPC

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